SCHEMBL8987909

SCHEMBL8987909

COCc1nccc(N(C(C)=O)c2ccc(Oc3ccc(C(F)(F)F)cc3)cc2)n1

nearest known ligand 0.37

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
MAOB P27338 2/20 0.37
LIPE Q05469 2/20 0.37
MMP2 P08253 2/20 0.37
MMP9 P14780 2/20 0.37
SCN9A Q15858 4/20 0.37
CSF1R P07333 1/20 0.36
BRAF P15056 1/20 0.35
MEN1 O00255 1/20 0.35
KMT2A Q03164 1/20 0.35
KDM4C Q9H3R0 2/20 0.35
RXRA P19793 1/20 0.35
NR1H2 P55055 1/20 0.35
NR1H3 Q13133 1/20 0.35
MAPK14 Q16539 1/20 0.35
KCNH2 Q12809 1/20 0.35
LMNA P02545 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8988022 0.89 MMP2 (0.38) MAOBLIPEMMP2MMP9SCN9A
SCHEMBL8987801 0.88 MAPK14 (0.42) MAOBSCN9AMAPK14
SCHEMBL8987991 0.87 KDM4C (0.37) MAOBMEN1KMT2AKDM4CRXRA
SCHEMBL8987689 0.86 MMP2 (0.38) MAOBMMP2MMP9SCN9ACSF1R
SCHEMBL8987790 0.84 LIPE (0.40) MAOBLIPEMMP2MMP9SCN9A
SCHEMBL8987860 0.82 SCN9A (0.38) MAOBLIPEMMP2MMP9SCN9A
SCHEMBL8987662 0.81 MMP2 (0.38) LIPEMMP2MMP9SCN9ACSF1R
SCHEMBL8987993 0.79 SCN9A (0.37) LIPEMMP2MMP9SCN9ABRAF
SCHEMBL8987708 0.78 CSF1R (0.41) MAOBLIPEMMP2MMP9SCN9A
SCHEMBL8987785 0.78 PROKR1 (0.38) LIPEMMP2MMP9SCN9ACSF1R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5556859-A N-(4-pyrimidinyl)amide pesticides DOWELANCO (US) 1996-09-17 US disclosed