Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 5/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | PPARD | Q03181 | 2/20 | 0.40 |
| ▸ | TDP2 | O95551 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | COMT | P21964 | 1/20 | 0.39 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24173752 | 0.84 | ALDH1A1 (0.50) | KIF11POLBSIGMAR1KDM4EALDH1A1 | |
| SCHEMBL3534328 | 0.83 | TP53 (0.45) | KIF11TP53GAAMAPTPOLB | |
| SCHEMBL8989158 | 0.78 | PPARD (0.47) | KIF11TP53GAAMAPTPOLB | |
| SCHEMBL8989180 | 0.78 | PPARD (0.40) | KIF11TP53GAAMAPTPOLB | |
| SCHEMBL15167073 | 0.78 | MEN1 (0.46) | TP53GAAMAPTPOLBSIGMAR1 | |
| SCHEMBL12759486 | 0.77 | TP53 (0.46) | TP53GAAMAPTPOLBHSD11B1 | |
| SCHEMBL8989228 | 0.76 | MAP4K4 (0.53) | TP53MAPTALDH1A1CYP1A2HSD11B1 | |
| SCHEMBL8453399 | 0.75 | HPGDS (0.58) | GAAMAPTKDM4EALDH1A1CYP1A2 | |
| SCHEMBL15168293 | 0.75 | SMN1; SMN2 (0.44) | TP53GAAMAPTPOLBKDM4E | |
| SCHEMBL11624181 | 0.74 | KIF11 (0.41) | KIF11TP53GAAMAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5545645-A | Heterocyclic derivatives in the treatment of ischaemia and related diseases | SYNTEX PHARMACEUTICALS, LIMITED (GB) | 1996-08-13 | — | — | US | disclosed |
| US-5428037-A | Piperazine derivatives; calcium and sodium channel antagonists | SYNTEX PHARMACEUTICALS, LTD. (GB) | 1995-06-27 | — | — | US | disclosed |