Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | KIF11 | P52732 | 2/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 3/20 | 0.41 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | TNKS | O95271 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8989237 | 0.84 | KIF11 (0.47) | ALDH1A1HPGDHSD17B10KDM4EPOLB | |
| SCHEMBL8989228 | 0.77 | MAP4K4 (0.53) | ALDH1A1SMN1; SMN2TSHRHSD11B1 | |
| SCHEMBL8453399 | 0.76 | HPGDS (0.58) | ALDH1A1HSD17B10KDM4ETDP1TSHR | |
| SCHEMBL8989181 | 0.74 | MAPT (0.51) | ALDH1A1HPGDHSD17B10KDM4EALOX15 | |
| SCHEMBL22845298 | 0.73 | POLB (0.45) | ALDH1A1HPGDHSD17B10KDM4EPOLB | |
| SCHEMBL14006037 | 0.72 | ALDH1A1 (0.51) | ALDH1A1HPGDHSD17B10KDM4EPOLB | |
| SCHEMBL10176272 | 0.70 | KIF11 (0.47) | ALDH1A1HPGDHSD17B10KDM4EPOLB | |
| SCHEMBL18520834 | 0.70 | ALDH1A1 (0.50) | ALDH1A1HPGDHSD17B10KDM4EPOLB | |
| SCHEMBL17752219 | 0.70 | ALDH1A1 (0.46) | ALDH1A1HPGDHSD17B10KDM4EPOLB | |
| SCHEMBL1544151 | 0.69 | ALDH1A1 (0.49) | ALDH1A1HPGDHSD17B10KDM4EPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220000874-A1 | TRICYCLIC COMPOUNDS | ALIGOS THERAPEUTICS, INC. | 2022-01-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220000874-A1 | TRICYCLIC COMPOUNDS | SLC10A1, PKD1, CEL | ALDH1A1 648/4885HPGD 1777/4885HSD17B10 200/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.