SCHEMBL8989501

SCHEMBL8989501

NC(=O)c1c[c]nc(F)n1

nearest known ligand 0.36

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.36
ADORA3 P0DMS8 1/20 0.31
TSHR P16473 1/20 0.31
MC4R P32245 1/20 0.31
ADRA1A P35348 1/20 0.31
MC3R P41968 1/20 0.31
CA5A P35218 1/20 0.31
KMT2A Q03164 1/20 0.31
NOTUM Q6P988 1/20 0.31
SIRT6 Q8N6T7 1/20 0.31
GRM2 Q14416 1/20 0.30
NPC1 O15118 1/20 0.30
RAB9A P51151 1/20 0.30
PIM1 P11309 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27435854 0.82 ALOX15 (0.37) LMNATSHR
SCHEMBL11700679 0.67 LMNA (0.48) LMNAGRM2PIM1
SCHEMBL31000446 0.65 ADORA3 (0.41) LMNAADORA3TSHRMC4RADRA1A
SCHEMBL18938717 0.63
SCHEMBL2445494 0.63
SCHEMBL6119150 0.61 NNMT (0.31)
SCHEMBL6885952 0.60
SCHEMBL5677092 0.59
SCHEMBL6377563 0.58 ADORA3 (0.47) LMNAADORA3TSHRMC4RADRA1A
SCHEMBL1852849 0.58 PIM1 (0.47) LMNATSHRCA5AGRM2PIM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5490866-A MIXTURE OF POLYVINYLPYRROLIDONE AND ALKALI SILICATE CIBA-GEIGY CORPORATION (US) 1996-02-13 US disclosed
EP-0286021-B1 REACTIVE AZO DYES BASF Aktiengesellschaft (DE) 1991-06-26 EP disclosed
US-4897469-A Aniline series azo reactive dyes ortho- or para-substituted by vinyl sulfonyl reactive groups BASF AKTIENGESELLSCHAFT (DE) 1990-01-30 US disclosed
US-4877413-A Process for the end-to-end dyeing of cellulosic fibres CIBA-GEIGY CORPORATION (US) 1989-10-31 US disclosed
US-4828572-A MONOAZO DYES CIBA-GEIGY CORPORATION (US) 1989-05-09 US disclosed
EP-0286021-A2 Reactive azo dyes BASF Aktiengesellschaft (DE) 1988-10-12 EP disclosed
US-4659333-A Process for fixing dyes and prints with hot steam containing air CIBA-GEIGY CORPORATION (US) 1987-04-21 US disclosed