Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES1 | P23141 | 2/20 | 0.62 |
| ▸ | MMP12 | P39900 | 1/20 | 0.62 |
| ▸ | MMP13 | P45452 | 1/20 | 0.62 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.55 |
| ▸ | CA2 | P00918 | 1/20 | 0.53 |
| ▸ | NOS1 | P29475 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | ALPL | P05186 | 1/20 | 0.49 |
| ▸ | ALPI | P09923 | 1/20 | 0.49 |
| ▸ | ALPG | P10696 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4574068 | 0.85 | MMP12 (0.82) | CES1MMP12MMP13CYP2C19CYP1A2 | |
| SCHEMBL4867754 | 0.82 | CES1 (0.61) | CES1MMP12MMP13CYP2C19CYP1A2 | |
| SCHEMBL1478837 | 0.81 | MEN1 (0.66) | CYP2C19CA2NOS1SMN1; SMN2LMNA | |
| SCHEMBL20707338 | 0.80 | ALDH1A1 (0.63) | CES1MMP12MMP13CYP2C19CYP1A2 | |
| Hydrochloric Acid SCHEMBL5506583 | 0.79 | MEN1 (0.63) | CYP2C19CA2NOS1SMN1; SMN2MAPT | |
| Bromide SCHEMBL3375119 | 0.79 | MEN1 (0.63) | CYP2C19CA2NOS1SMN1; SMN2LMNA | |
| Carbamic Acid SCHEMBL2222080 | 0.77 | FFAR1 (0.62) | CES1NOS1SMN1; SMN2KEAP1LMNA | |
| Urea SCHEMBL2006220 | 0.77 | FFAR1 (0.62) | CES1NOS1SMN1; SMN2KEAP1LMNA | |
| SCHEMBL6049236 | 0.77 | NOS1 (0.64) | CES1MMP12MMP13CYP2C19CYP1A2 | |
| SCHEMBL577806 | 0.77 | CYP1A2 (0.76) | CES1MMP12MMP13CYP2C19CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5563250-A | Cleavable conjugates for the delivery and release of agents in native form | NEORX CORPORATION (US) | 1996-10-08 | — | — | US | disclosed |
| US-5141648-A | Methods for isolating compounds using cleavable linker bound matrices | NEORX CORPORATION (US) | 1992-08-25 | — | — | US | disclosed |
| EP-0318948-B1 | CLEAVABLE IMMUNOCONJUGATES FOR THE DELIVERY AND RELEASE OF AGENTS IN NATIVE FORM | NEORX CORPORATION (US) | 1992-08-19 | — | — | EP | disclosed |
| US-5017693-A | Methods for introducing a sulfhydryl amino or hydroxyl groups to a compound | NEORX CORPORATION (US) | 1991-05-21 | — | — | US | disclosed |
| EP-0318948-A2 | Cleavable immunoconjugates for the delivery and release of agents in native form | NEORX CORPORATION (US) | 1989-06-07 | — | — | EP | disclosed |