Sugi Predict

Sugi Predict / Compounds / SCHEMBL899057

SCHEMBL899057

SCHEMBL899057

Nc1cc(Br)cnc1[N+](=O)[O-]

nearest known ligand 0.41

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 3/20 0.41
▸ KMT2A Q03164 3/20 0.41
▸ HTT P42858 1/20 0.41
▸ ALDH1A1 P00352 5/20 0.39
▸ CYP3A4 P08684 3/20 0.39
▸ TDP1 Q9NUW8 5/20 0.37
▸ ALOX15 P16050 2/20 0.37
▸ TSHR P16473 2/20 0.37
▸ MEN1 O00255 2/20 0.37
▸ POLB P06746 2/20 0.37
▸ DYRK1A Q13627 1/20 0.37
▸ HPGD P15428 1/20 0.36
▸ CTSB P07858 1/20 0.35
▸ GPR35 Q9HC97 1/20 0.34
▸ PKM P14618 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8562235 0.80 TDP1 (0.48) MAPTKMT2AALDH1A1CYP3A4TDP1
SCHEMBL31475345 0.80 MAPT (0.47) MAPTKMT2AHTTALDH1A1CYP3A4
SCHEMBL16684526 0.80 POLB (0.49) MAPTKMT2AALDH1A1CYP3A4TDP1
SCHEMBL26159111 0.79 ALDH1A1 (0.39) MAPTKMT2AHTTALDH1A1CYP3A4
SCHEMBL28874590 0.77 PDE7A (0.37) MAPTKMT2AHTTALDH1A1CYP3A4
SCHEMBL711811 0.77 MAPT (0.37) MAPTKMT2AALDH1A1CYP3A4TDP1
SCHEMBL203876 0.77 KMT2A (0.50) MAPTKMT2AHTTALDH1A1CYP3A4
SCHEMBL28760235 0.77 MAPT (0.41) MAPTKMT2AHTTTDP1MEN1
SCHEMBL2586421 0.77 MAPT (0.41) MAPTKMT2AHTTALDH1A1TDP1
SCHEMBL15616434 0.77 MAPT (0.41) MAPTKMT2AHTTALDH1A1TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 101 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4618977-A1 LRRK2 INHIBITORS AND USES THEREOF Neuron23, Inc. (US) 2025-09-24 — — EP disclosed
CN-119707930-A Aromatic ring compound and its prepn and use 甘李药业股份有限公司 2025-03-28 — — CN disclosed
US-20250059165-A1 PIPERIDINYLPYRIDINYLCARBONITRILE DERIVATIVES AS INHIBITORS OF GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE AND GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE LIKE PROTEIN BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2025-02-20 — — US disclosed
WO-2025031918-A1 PIPERIDINYLPYRIDINYLCARBONITRILE DERIVATIVES AS INHIBITORS OF GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE AND GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE LIKE PROTEIN BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2025-02-13 — — WO disclosed
US-20240228493-A1 LRRK2 INHIBITORS AND USES THEREOF NEURON23, INC. 2024-07-11 — — US disclosed
US-20240228493-A1 LRRK2 INHIBITORS AND USES THEREOF NEURON23, INC. 2024-07-11 — — US disclosed
WO-2024108116-A1 LRRK2 INHIBITORS AND USES THEREOF NEURON23, INC. (US) 2024-05-23 — — WO disclosed
US-11858939-B2 Hetero-halo inhibitors of histone deacetylase ALKERMES, INC. (US) 2024-01-02 — — US disclosed
EP-3674300-B1 NOVEL BICYCLIC BROMODOMAIN INHIBITORS ZENITH EPIGENETICS LTD (CA) 2022-10-12 — — EP disclosed
US-11446306-B2 Bicyclic bromodomain inhibitors ZENITH EPIGENETICS LTD. (CA) 2022-09-20 — — US disclosed
WO-2009005638-A2 PYRIDYL AND PYRIMIDINYL DERIVATIVES AS HISTONE DEACETYLASE INHIBITORS MERCK & CO., INC. (US) 2009-01-08 — — WO disclosed
US-20070249600-A1 CHEMICAL COMPOUNDS CHEUNG MUI 2007-10-25 — — US disclosed
US-20070249600-A1 CHEMICAL COMPOUNDS CHEUNG MUI 2007-10-25 — — US disclosed
US-20070249600-A1 CHEMICAL COMPOUNDS CHEUNG MUI 2007-10-25 — — US disclosed
US-7238813-B2 Chemical compounds SMITHKLINE BEECHAM CORPORATION (US) 2007-07-03 — — US disclosed
US-7238813-B2 Chemical compounds SMITHKLINE BEECHAM CORPORATION (US) 2007-07-03 — — US disclosed
US-7238813-B2 Chemical compounds SMITHKLINE BEECHAM CORPORATION (US) 2007-07-03 — — US disclosed
US-20040082583-A1 Chemical compounds SMITHKLINE BEECHAM CORPORATION 2004-04-29 — — US disclosed
EP-1341771-A2 BENZIMIDAZOLE DERIVATIVES USEFUL AS TIE-2 AND/OR VEGFR-2 INHIBITORS GLAXO GROUP LIMITED (GB) 2003-09-10 — — EP disclosed
WO-2002044156-A2 BENZIMIDAZOLE DERIVATIVES USEFUL AS TIE-2 AND/OR VEGFR-2 INHIBITORS GLAXO GROUP LIMITED (GB) 2002-06-06 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11858939-B2 Hetero-halo inhibitors of histone deacetylase HDAC2, HDAC1, HDAC6 MAPT 475/4885KMT2A 48/4885HTT 279/4885
US-20070249600-A1 CHEMICAL COMPOUNDS TIE1, KDR, FLT4 MAPT 2991/4885KMT2A 165/4885HTT 3099/4885
US-11446306-B2 Bicyclic bromodomain inhibitors BRD4, BRD3, BRD2 MAPT 810/4885KMT2A 305/4885HTT 1440/4885
US-20040082583-A1 Chemical compounds TIE1, KDR, FLT4 MAPT 2991/4885KMT2A 165/4885HTT 3099/4885
US-20250059165-A1 PIPERIDINYLPYRIDINYLCARBONITRILE DERIVATIVES AS INHIBITORS OF GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE AND GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE LIKE PROTEIN QPCT, QPCTL, GLUL MAPT 1005/4885KMT2A 1601/4885HTT 205/4885
US-20240228493-A1 LRRK2 INHIBITORS AND USES THEREOF LRRK2, PINK1, PARK7 MAPT 151/4885KMT2A 1240/4885HTT 73/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.