Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AOC3 | Q16853 | 5/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | DHFR | P00374 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.34 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27631895 | 0.69 | DHFR (0.45) | AOC3LMNAKDM4EL3MBTL1CYP2D6 | |
| SCHEMBL9646578 | 0.68 | AOC3 (0.47) | AOC3LMNAKDM4EL3MBTL1BCAT2 | |
| SCHEMBL9660286 | 0.67 | LMNA (0.46) | AOC3LMNAKDM4EL3MBTL1CYP2D6 | |
| SCHEMBL9658892 | 0.67 | LMNA (0.50) | AOC3LMNAKDM4EL3MBTL1CYP2D6 | |
| SCHEMBL9660899 | 0.67 | LMNA (0.46) | AOC3LMNAKDM4EL3MBTL1CYP2D6 | |
| SCHEMBL9660894 | 0.67 | LMNA (0.46) | AOC3LMNAKDM4EL3MBTL1CYP2D6 | |
| SCHEMBL9658896 | 0.67 | LMNA (0.50) | AOC3LMNAKDM4EL3MBTL1CYP2D6 | |
| SCHEMBL9660282 | 0.67 | LMNA (0.46) | AOC3LMNAKDM4EL3MBTL1CYP2D6 | |
| SCHEMBL8352649 | 0.66 | SOAT1 (0.53) | AOC3LMNAKDM4EL3MBTL1 | |
| SCHEMBL2021 | 0.66 | TAAR1 (0.62) | AOC3LMNAKDM4EL3MBTL1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5500428-A | Furyl-substituted purines and adenosine antagonists | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1996-03-19 | — | — | US | disclosed |
| US-5300509-A | Adenosine antagonists for treating cardiovascular disorders, vasodilation | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1994-04-05 | — | — | US | disclosed |
| EP-0544445-A2 | Furyl-substituted purines, oxazolopyrimidines and pteridines as adenosine antagonists | ZENECA LIMITED (GB) | 1993-06-02 | — | — | EP | disclosed |