Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 3/20 | 0.42 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.36 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | FEN1 | P39748 | 1/20 | 0.32 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.32 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.32 |
| ▸ | DPP4 | P27487 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | GALR3 | O60755 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.32 |
| ▸ | FAP | Q12884 | 1/20 | 0.31 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.31 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25342826 | 0.86 | ABCB1 (0.40) | MDM2SIRT2SIRT1P2RX7 | |
| SCHEMBL25342831 | 0.86 | ABCB1 (0.40) | MDM2SIRT2SIRT1P2RX7 | |
| SCHEMBL6835149 | 0.75 | LMNA (0.34) | MDM2LMNASMN1; SMN2 | |
| SCHEMBL6063753 | 0.73 | ELANE (0.36) | MDM2TSHRSMN1; SMN2ALDH1A1 | |
| SCHEMBL6063582 | 0.73 | ELANE (0.36) | MDM2TSHRSMN1; SMN2ALDH1A1 | |
| SCHEMBL7262995 | 0.73 | SIGMAR1 (0.35) | MDM2LMNASMN1; SMN2 | |
| SCHEMBL6918361 | 0.72 | ELANE (0.35) | TSHRSMN1; SMN2KMT2AALDH1A1 | |
| SCHEMBL22636048 | 0.72 | ELANE (0.35) | TSHRSMN1; SMN2KMT2AALDH1A1 | |
| SCHEMBL9236157 | 0.71 | MGAM (0.34) | MDM2LMNASMN1; SMN2 | |
| SCHEMBL7063555 | 0.71 | MAPT (0.32) | MDM2SMN1; SMN2KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5545735-A | ANIMAL GROWTH REGULATORS | MERCK & CO., INC. (US) | 1996-08-13 | — | — | US | disclosed |
| WO-1995009633-A1 | BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO., INC. (US) | 1995-04-13 | — | — | WO | disclosed |