Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.35 |
| ▸ | FAAH | O00519 | 1/20 | 0.33 |
| ▸ | SLC18A3 | Q16572 | 2/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | DRD1 | P21728 | 1/20 | 0.32 |
| ▸ | DRD4 | P21917 | 1/20 | 0.32 |
| ▸ | DRD5 | P21918 | 1/20 | 0.32 |
| ▸ | DRD3 | P35462 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.31 |
| ▸ | MAOB | P27338 | 1/20 | 0.31 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.31 |
| ▸ | MMP2 | P08253 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6835149 | 0.87 | LMNA (0.34) | SIGMAR1FAAHLMNACYP1A2CYP2C9 | |
| SCHEMBL9236157 | 0.84 | MGAM (0.34) | LMNACYP1A2CYP2C9CYP2C19RECQL | |
| SCHEMBL7898909 | 0.82 | S1PR3 (0.39) | — | |
| SCHEMBL7898908 | 0.82 | MDM2 (0.34) | MDM2 | |
| SCHEMBL6063753 | 0.73 | ELANE (0.36) | SMN1; SMN2NPSR1MDM2 | |
| SCHEMBL6063582 | 0.73 | ELANE (0.36) | SMN1; SMN2NPSR1MDM2 | |
| SCHEMBL7892968 | 0.73 | ABCB1 (0.40) | — | |
| SCHEMBL7892970 | 0.73 | ABCB1 (0.40) | — | |
| SCHEMBL8990837 | 0.73 | MDM2 (0.42) | LMNASMN1; SMN2MDM2 | |
| SCHEMBL9238321 | 0.72 | PTGDR2 (0.31) | DRD2CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0728018-B1 | New enzymes and prodrugs for ADEPT | WELLCOME FOUND (GB) | 2003-08-06 | — | — | EP | disclosed |
| US-6319702-B1 | NUCLEOTIDE SEQUENCS CODING AN ENZYMATIC POLYPEPTIDE AND CELL TARGETING COMPOUND; FOR USE IN TREATMENT OF CANCER | GLAXO WELLCOME, INC. | 2001-11-20 | — | — | US | disclosed |
| US-6140100-A | CONJUGATE POLYPEPTIDE WHICH IS TISSUE PREFERENTIAL; ANTICARCINOGENIC AGENTS | GLAXO WELLCOME INC. (US) | 2000-10-31 | — | — | US | disclosed |
| EP-0728018-A1 | THERAPY | THE WELLCOME FOUNDATION LIMITED (GB) | 1996-08-28 | — | — | EP | disclosed |
| WO-1995013095-A2 | THERAPY | THE WELLCOME FOUNDATION LIMITED (GB) | 1995-05-18 | — | — | WO | disclosed |