Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 1/20 | 0.38 |
| ▸ | TACR1 | P25103 | 1/20 | 0.36 |
| ▸ | ACE | P12821 | 3/20 | 0.35 |
| ▸ | MME | P08473 | 2/20 | 0.35 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.34 |
| ▸ | ANPEP | P15144 | 2/20 | 0.34 |
| ▸ | LNPEP | Q9UIQ6 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8990942 | 0.94 | PRMT5 (0.38) | PRMT5TACR1ACEMMEHRH4 | |
| SCHEMBL8990867 | 0.92 | CCR3 (0.34) | TACR1HDAC1HDAC7 | |
| SCHEMBL8991074 | 0.91 | AGTR1 (0.35) | — | |
| SCHEMBL8990688 | 0.91 | HDAC1 (0.31) | PRMT5TACR1MMEHDAC1HDAC7 | |
| SCHEMBL8990954 | 0.87 | CCR3 (0.33) | PRMT5TACR1HDAC1HDAC7 | |
| SCHEMBL8990819 | 0.86 | PRMT5 (0.32) | PRMT5TACR1HDAC1HDAC7 | |
| SCHEMBL8991043 | 0.86 | AGTR1 (0.34) | PRMT5 | |
| SCHEMBL8990976 | 0.85 | ANPEP (0.40) | PRMT5ACEMMEHRH4HDAC1 | |
| SCHEMBL8990812 | 0.82 | GHSR (0.47) | TACR1ACEMMEHRH4HDAC1 | |
| SCHEMBL8990818 | 0.82 | GHSR (0.47) | TACR1ACEMMEHRH4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5545735-A | ANIMAL GROWTH REGULATORS | MERCK & CO., INC. (US) | 1996-08-13 | — | — | US | claimed |
| WO-1995009633-A1 | BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO., INC. (US) | 1995-04-13 | — | — | WO | claimed |
| US-5545735-A | ANIMAL GROWTH REGULATORS | MERCK & CO., INC. (US) | 1996-08-13 | — | — | US | disclosed |
| WO-1995009633-A1 | BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO., INC. (US) | 1995-04-13 | — | — | WO | disclosed |