Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
| ▸ | NR1H4 | Q96RI1 | 6/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.36 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.35 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.34 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8991078 | 0.89 | PDE4A (0.42) | PDE4APDE4BPDE4CPDE4DTP53 | |
| SCHEMBL8991397 | 0.89 | PDE4A (0.51) | PDE4APDE4BPDE4CPDE4DFLT3 | |
| SCHEMBL8991275 | 0.87 | FLT3 (0.43) | NR1H4FLT3ABCC8KCNJ11ICMT | |
| SCHEMBL8991143 | 0.86 | HDAC1 (0.46) | PDE4APDE4BPDE4CPDE4DYTHDC1 | |
| SCHEMBL8991272 | 0.82 | PDE4A (0.38) | PDE4APDE4BPDE4CPDE4DNR1H4 | |
| SCHEMBL8991141 | 0.81 | PDE4A (0.38) | PDE4APDE4BPDE4CPDE4DNR1H4 | |
| SCHEMBL8991264 | 0.81 | PDE4A (0.38) | PDE4APDE4BPDE4CPDE4DNR1H4 | |
| SCHEMBL8991237 | 0.79 | PDE4A (0.42) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8991346 | 0.76 | PDE4A (0.40) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL8990936 | 0.76 | ADK (0.33) | PDE4APDE4BPDE4CPDE4DFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5543413-A | VIRAL ACTIVITY AGAINST HUMAN CYTOMEGALOVIRUS AND HERPES SIMPLEX VIRUS | REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 1996-08-06 | — | — | US | disclosed |