Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 3/20 | 0.51 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.51 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.51 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
| ▸ | YTHDC1 | Q96MU7 | 3/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | BRD2 | P25440 | 1/20 | 0.39 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.39 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | PDE5A | O76074 | 2/20 | 0.39 |
| ▸ | PDE1A | P54750 | 2/20 | 0.39 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8991078 | 0.91 | PDE4A (0.42) | PDE4APDE4BPDE4CPDE4DMEN1 | |
| SCHEMBL8991152 | 0.89 | PDE4A (0.40) | PDE4APDE4BPDE4CPDE4DYTHDC1 | |
| SCHEMBL8991143 | 0.89 | HDAC1 (0.46) | PDE4APDE4BPDE4CPDE4DNPC1 | |
| SCHEMBL8991237 | 0.87 | PDE4A (0.42) | PDE4APDE4BPDE4CPDE4DMEN1 | |
| SCHEMBL8991346 | 0.86 | PDE4A (0.40) | PDE4APDE4BPDE4CPDE4DMEN1 | |
| SCHEMBL8991302 | 0.84 | ADORA2A (0.49) | HTTEGFRSRCKDM4EFLT3 | |
| SCHEMBL8991110 | 0.81 | PDE4A (0.50) | PDE4APDE4BPDE4CPDE4DMEN1 | |
| SCHEMBL8990936 | 0.80 | ADK (0.33) | PDE4APDE4BPDE4CPDE4DEGFR | |
| SCHEMBL8991388 | 0.80 | PDE4A (0.50) | PDE4APDE4BPDE4CPDE4DMEN1 | |
| SCHEMBL8991103 | 0.80 | PDE4A (0.50) | PDE4APDE4BPDE4CPDE4DMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5543413-A | VIRAL ACTIVITY AGAINST HUMAN CYTOMEGALOVIRUS AND HERPES SIMPLEX VIRUS | REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 1996-08-06 | — | — | US | disclosed |