Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 4/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.39 |
| ▸ | PDE5A | O76074 | 2/20 | 0.38 |
| ▸ | PDE1A | P54750 | 2/20 | 0.38 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.38 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 4/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 4/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8991133 | 0.89 | HTT (0.45) | PDE4APDE4BPDE4CPDE4DAURKA | |
| SCHEMBL8991361 | 0.87 | MEN1 (0.46) | PDE4APDE4BPDE4CPDE4DMEN1 | |
| SCHEMBL8991288 | 0.83 | MEN1 (0.40) | PDE4APDE4BPDE4CPDE4DRPS6KB1 | |
| SCHEMBL8991137 | 0.83 | AURKA (0.40) | PDE4APDE4BPDE4CPDE4DAURKA | |
| SCHEMBL8991129 | 0.82 | PDE4A (0.41) | PDE4APDE4BPDE4CPDE4DAURKA | |
| SCHEMBL8991122 | 0.80 | PDE4A (0.41) | PDE4APDE4BPDE4CPDE4DAURKA | |
| SCHEMBL8991296 | 0.80 | PDE4A (0.41) | PDE4APDE4BPDE4CPDE4DAURKA | |
| SCHEMBL8991237 | 0.80 | PDE4A (0.42) | PDE4APDE4BPDE4CPDE4DAURKA | |
| SCHEMBL8991066 | 0.79 | ALDH1A1 (0.44) | AURKARPS6KB1PDE1BMEN1KMT2A | |
| SCHEMBL8991176 | 0.77 | XDH (0.31) | PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5543413-A | VIRAL ACTIVITY AGAINST HUMAN CYTOMEGALOVIRUS AND HERPES SIMPLEX VIRUS | REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 1996-08-06 | — | — | US | disclosed |