Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | TOP2A | P11388 | 2/20 | 0.44 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5410967 | 0.81 | MTNR1A (0.49) | TDP1NPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL28084519 | 0.81 | ALDH1A1 (0.50) | LMNAMTNR1AMTNR1BSIGMAR1 | |
| SCHEMBL9681177 | 0.81 | TSHR (0.46) | TDP1NPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL28008271 | 0.81 | TSHR (0.46) | TDP1NPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL28633131 | 0.80 | SMN1; SMN2 (0.51) | SMN1; SMN2TOP2AMTNR1AMTNR1BCYP3A4 | |
| SCHEMBL2342436 | 0.80 | HRH1 (0.48) | TDP1SMN1; SMN2MTNR1AMTNR1BSIGMAR1 | |
| SCHEMBL2342435 | 0.80 | MTNR1A (0.49) | TDP1SMN1; SMN2MTNR1AMTNR1BSIGMAR1 | |
| SCHEMBL19792371 | 0.80 | NPC1 (0.47) | TDP1NPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL9773152 | 0.80 | NPC1 (0.62) | NPC1RAB9ASMN1; SMN2LMNATSHR | |
| SCHEMBL9773153 | 0.80 | NPC1 (0.62) | NPC1RAB9ASMN1; SMN2LMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5589501-A | TREATMENT OF NEUROLOGICAL DISEASES, ANTIPSYCHOTIC, ANTICONVULSANT, ANALGESIC AND ANTIEMETIC AGENT | ELI LILLY AND COMPANY (US) | 1996-12-31 | — | — | US | disclosed |