Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A known ✓ | P28223 | 13/20 | 0.44 |
| ▸ | DRD2 known ✓ | P14416 | 12/20 | 0.44 |
| ▸ | KCNH2 known ✓ | Q12809 | 9/20 | 0.44 |
| ▸ | HTR1A known ✓ | P08908 | 2/20 | 0.44 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.43 |
| ▸ | HTR7 | P34969 | 11/20 | 0.44 |
| ▸ | ACHE | P22303 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL8915770 | 1.00 | HTR2A (0.44) | HTR2ADRD2HTR7KCNH2HTR1A | |
| SCHEMBL8916675 | 0.81 | DRD2 (0.49) | HTR2ADRD2HTR7KCNH2HTR1A | |
| Oxalic Acid SCHEMBL8917312 | 0.78 | DRD2 (0.53) | HTR2ADRD2KCNH2HTR1AACHE | |
| Fumaric Acid SCHEMBL8156168 | 0.75 | DRD2 (0.60) | HTR2ADRD2HTR7KCNH2ACHE | |
| Fumaric Acid SCHEMBL8156164 | 0.75 | DRD2 (0.60) | HTR2ADRD2HTR7KCNH2ACHE | |
| SCHEMBL8917307 | 0.74 | DRD2 (0.58) | HTR2ADRD2HTR7KCNH2ACHE | |
| Fumaric Acid SCHEMBL1545783 | 0.74 | HTR2A (0.60) | HTR2ADRD2HTR7KCNH2HTR1A | |
| Fumaric Acid SCHEMBL1545788 | 0.74 | HTR2A (0.60) | HTR2ADRD2HTR7KCNH2HTR1A | |
| Fumaric Acid SCHEMBL1545786 | 0.74 | HTR2A (0.60) | HTR2ADRD2HTR7KCNH2HTR1A | |
| Fumaric Acid SCHEMBL5992737 | 0.74 | HTR2A (0.60) | HTR2ADRD2HTR7KCNH2HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5532240-A | ANTIPSYCHOTIC AGENTS AND ANTISEROTONIN AGENTS | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1996-07-02 | — | — | US | disclosed |
| EP-0596125-A1 | CONDENSED THIOPHENE COMPOUND AND PHARMACEUTICAL USE THEREOF | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1994-05-11 | — | — | EP | disclosed |