SCHEMBL8992255

SCHEMBL8992255

C#Cc1ccc(C[SiH2]c2ccccc2)cc1

nearest known ligand 0.47

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
CYP2C9 P11712 3/20 0.34
FFAR1 O14842 3/20 0.33
HDAC8 Q9BY41 1/20 0.31
CA12 O43570 1/20 0.31
CA1 P00915 1/20 0.31
CA2 P00918 1/20 0.31
CA4 P22748 1/20 0.31
CA9 Q16790 1/20 0.31
CA14 Q9ULX7 1/20 0.31
PTPN1 P18031 1/20 0.30
FFAR4 Q5NUL3 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13169409 0.83 TSHR (0.39)
SCHEMBL3683423 0.79 TSHR (0.46)
SCHEMBL1921158 0.73 CALM1 (0.57) CYP2C9CA12CA1CA2CA9
SCHEMBL2498577 0.71 LTA4H (0.53) FFAR1CA1CA2FFAR4
SCHEMBL13169410 0.69 TSHR (0.40)
Phenylacetylene SCHEMBL4297769 0.68
Phenylacetylene SCHEMBL1331558 0.68
Phenylacetylene SCHEMBL1331398 0.68
Phenylacetylene SCHEMBL1331408 0.68
Phenylacetylene SCHEMBL6891916 0.68 APP (0.53) CYP2C9HDAC8CA12CA1CA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5516871-A Diphenylsiloxane oligomers functionalized at both terminals and methods for the preparation thereof DOW CORNING ASIA, LTD. (JP) 1996-05-14 US claimed
US-5502229-A ENDCAPPING DOW CORNING ASIA, LTD. (JP) 1996-03-26 US claimed
US-5516871-A Diphenylsiloxane oligomers functionalized at both terminals and methods for the preparation thereof DOW CORNING ASIA, LTD. (JP) 1996-05-14 US disclosed
US-5502229-A ENDCAPPING DOW CORNING ASIA, LTD. (JP) 1996-03-26 US disclosed