Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 2/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.37 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.36 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.35 |
| ▸ | BRS3 | P32247 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9053263 | 0.78 | AGTR1 (0.49) | AGTR1LMNASMN1; SMN2AGTR2 | |
| SCHEMBL9248272 | 0.76 | BRS3 (0.38) | AGTR1LMNASMN1; SMN2AGTR2BRS3 | |
| SCHEMBL1894561 | 0.76 | ACHE (0.45) | PPARGACHEAGTR1PDE3BPDE3A | |
| SCHEMBL4011017 | 0.75 | PPARG (0.43) | PPARGACHEAGTR1PDE3BPDE3A | |
| SCHEMBL4010291 | 0.74 | PPARG (0.40) | PPARGACHEAGTR1ALDH1A1HPGD | |
| SCHEMBL4011221 | 0.74 | PPARG (0.43) | PPARGACHEAGTR1PDE3BPDE3A | |
| SCHEMBL8992687 | 0.74 | PPARG (0.53) | PPARGACHEAGTR1ALDH1A1LMNA | |
| SCHEMBL1886733 | 0.73 | PPARG (0.45) | PPARGACHEAGTR1 | |
| SCHEMBL9054292 | 0.73 | ACHE (0.44) | ACHEAGTR1AGTR2BRS3 | |
| SCHEMBL9247811 | 0.73 | AGTR1 (0.47) | ACHEAGTR1AGTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5510354-A | HYPOTENSIVE AGENTS | TANABE SEIYAKU CO., LTD. (JP) | 1996-04-23 | — | — | US | disclosed |
| US-5424316-A | Imidazopyridine derivatives for the treatment of hypertension | TANABE SEIYAKU CO., LTD. (JP) | 1995-06-13 | — | — | US | disclosed |
| US-5409936-A | Useful in prophylaxix; exhibits potent angiotensin ii inhibitory acivities | TANABE SEIYAKU CO., LTD. (JP) | 1995-04-25 | — | — | US | disclosed |
| EP-0531874-A1 | Imidazopyridine derivatives and process for preparation thereof | TANABE SEIYAKU CO., LTD. (JP) | 1993-03-17 | — | — | EP | disclosed |