Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | BRS3 | P32247 | 9/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.35 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9248272 | 0.90 | BRS3 (0.38) | BRS3AGTR1AGTR2 | |
| SCHEMBL9043004 | 0.87 | BRS3 (0.42) | ACHEBRS3AGTR1AGTR2 | |
| SCHEMBL9045987 | 0.81 | ACHE (0.42) | ACHEBRS3AGTR1AGTR2 | |
| SCHEMBL9054291 | 0.75 | ACHE (0.50) | ACHEAGTR1AGTR2 | |
| SCHEMBL9248176 | 0.74 | AGTR1 (0.46) | AGTR1AGTR2 | |
| SCHEMBL1257997 | 0.74 | ACHE (0.57) | ACHE | |
| SCHEMBL8992690 | 0.73 | PPARG (0.44) | ACHEBRS3AGTR1AGTR2 | |
| SCHEMBL9044849 | 0.73 | BRS3 (0.45) | ACHEBRS3AGTR1AGTR2 | |
| SCHEMBL8671888 | 0.70 | ACHE (0.49) | ACHEBRS3AGTR1AGTR2 | |
| SCHEMBL8802322 | 0.69 | ACHE (0.49) | ACHEBRS3AGTR1AGTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0531876-B1 | Imidazoindolizine derivatives and process for preparation thereof | TANABE SEIYAKU CO (JP) | 1996-12-18 | — | — | EP | disclosed |
| US-5268377-A | Imidazoindolizine derivatives process for preparation thereof and use thereof to treat hypertension | TANABE SEIYAKU CO., LTD. (JP) | 1993-12-07 | — | — | US | disclosed |
| EP-0531876-A2 | Imidazoindolizine derivatives and process for preparation thereof | TANABE SEIYAKU CO., LTD. (JP) | 1993-03-17 | — | — | EP | disclosed |