SCHEMBL899318

SCHEMBL899318

O=C(O)C=CC(F)(F)C(F)(F)F

nearest known ligand 0.44

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
TSHR P16473 3/20 0.44
TP53 P04637 1/20 0.44
EGLN1 Q9GZT9 1/20 0.44
EGLN3 Q9H6Z9 1/20 0.44
LMNA P02545 2/20 0.35
GABRR1 P24046 2/20 0.32
GABRR2 P28476 2/20 0.32
BLM P54132 2/20 0.32
GABRR3 A8MPY1 1/20 0.32
APEX1 P27695 1/20 0.32
NPSR1 Q6W5P4 1/20 0.32
TDP1 Q9NUW8 1/20 0.32
HCAR2 Q8TDS4 1/20 0.31
THRB P10828 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL899316 1.00 TSHR (0.44) TSHRTP53EGLN1EGLN3LMNA
SCHEMBL15754827 0.83 TSHR (0.40) TSHRTP53EGLN1EGLN3LMNA
SCHEMBL29210964 0.81 TSHR (0.38) TSHRTP53EGLN1EGLN3LMNA
SCHEMBL453090 0.80 TSHR (0.42) TSHRTP53EGLN1EGLN3LMNA
SCHEMBL7821073 0.80 TSHR (0.42) TSHRTP53EGLN1EGLN3LMNA
SCHEMBL9187017 0.80 TSHR (0.42) TSHRTP53EGLN1EGLN3LMNA
SCHEMBL28564049 0.79 THRB (0.46) TSHRTP53EGLN1EGLN3LMNA
SCHEMBL32685382 0.79 THRB (0.46) TSHRTP53EGLN1EGLN3LMNA
SCHEMBL8830567 0.79 THRB (0.46) TSHRTP53EGLN1EGLN3LMNA
SCHEMBL16178793 0.79 THRB (0.46) TSHRTP53EGLN1EGLN3LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4291587-A1 PHOTOPOLYMERIZABLE HOE COMPOSITION Xetos AG (DE) 2023-12-20 EP disclosed
EP-4291951-A1 TWO-COMPONENT SYSTEM Xetos AG (DE) 2023-12-20 EP disclosed
EP-4043502-B1 PHOTOPOLYMERIZABLE HOE COMPOSITION XETOS AG (DE) 2023-10-04 EP disclosed
EP-4043961-B1 2K SYSTEM XETOS AG (DE) 2023-08-16 EP disclosed
EP-4043962-B1 PHOTOPOLYMERIZABLE COMPOSITION XETOS AG (DE) 2023-06-07 EP disclosed
WO-2022171821-A1 PHOTOPOLYMERIZABLE HOE COMPOSITION XETOS AG (DE) 2022-08-18 WO disclosed
WO-2022171823-A1 PHOTOPOLYMERIZABLE COMPOSITION XETOS AG (DE) 2022-08-18 WO disclosed
WO-2022171814-A1 TWO-COMPONENT SYSTEM XETOS AG (DE) 2022-08-18 WO disclosed
EP-4043961-A1 2K SYSTEM Xetos AG (DE) 2022-08-17 EP disclosed
EP-4043962-A1 PHOTOPOLYMERIZABLE COMPOSITION Xetos AG (DE) 2022-08-17 EP disclosed
EP-2621903-A1 N-HETEROARYL COMPOUNDS Intervet International B.V. (NL) 2013-08-07 EP disclosed
US-20130196993-A1 N-HETEROARYL COMPOUNDS INTERVET INC. 2013-08-01 US disclosed
US-8431332-B2 Composition for forming upper layer film for immersion exposure, upper layer film for immersion exposure, and method of forming photoresist pattern JSR CORPORATION (JP) 2013-04-30 US disclosed
WO-2012041873-A1 N-HETEROARYL COMPOUNDS INTERVET INTERNATIONAL B.V. (NL) 2012-04-05 WO disclosed
EP-1438634-B1 HOLOGRAPHIC RECORDING MATERIAL AND METHOD FOR CREATING A LIGHT-RESISTANT HOLOGRAM XETOS AG (DE) 2011-03-16 EP disclosed
US-20100255416-A1 COMPOSITION FOR FORMING UPPER LAYER FILM FOR IMMERSION EXPOSURE, UPPER LAYER FILM FOR IMMERSION EXPOSURE, AND METHOD OF FORMING PHOTORESIST PATTERN JSR CORPORATION (JP) 2010-10-07 US disclosed
US-20100112458-A1 Photopolymerisable composition XETOS AG (DE) 2010-05-06 US disclosed
US-20100040974-A1 UPPER LAYER FILM FORMING COMPOSITION AND METHOD OF FORMING PHOTORESIST PATTERN JSR CORPORATION (JP) 2010-02-18 US disclosed
EP-1438634-A1 HOLOGRAPHIC RECORDING MATERIAL AND METHOD FOR CREATING A LIGHT-RESISTANT HOLOGRAM Xetos AG (DE) 2004-07-21 EP disclosed
WO-2003036389-A1 HOLOGRAPHIC RECORDING MATERIAL AND METHOD FOR CREATING A LIGHT-RESISTANT HOLOGRAM XETOG AG (DE) 2003-05-01 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130196993-A1 N-HETEROARYL COMPOUNDS HNMT, SQLE, PIGO TSHR 4440/4885TP53 4822/4885EGLN1 696/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.