Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 2/20 | 0.40 |
| ▸ | CHRM1 known ✓ | P11229 | 2/20 | 0.40 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 6/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 6/20 | 0.43 |
| ▸ | BLM | P54132 | 3/20 | 0.43 |
| ▸ | GALR3 | O60755 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | HRH1 | P35367 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 5/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.40 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | GMNN | O75496 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9340152 | 0.98 | LMNA (0.43) | LMNASMN1; SMN2MAPTBLMGALR3 | |
| SCHEMBL20681001 | 0.98 | LMNA (0.43) | LMNASMN1; SMN2MAPTBLMGALR3 | |
| Hydrochloric Acid SCHEMBL2794482 | 0.86 | LMNA (0.46) | LMNASMN1; SMN2MAPTBLMGALR3 | |
| SCHEMBL35385 | 0.82 | TSHR (0.45) | MAPTTSHRMAPK1ALDH1A1THRB | |
| Hydrochloric Acid SCHEMBL27784122 | 0.79 | MAPT (0.47) | LMNASMN1; SMN2MAPTBLMGALR3 | |
| SCHEMBL27660072 | 0.79 | LMNA (0.40) | LMNASMN1; SMN2MAPTBLMGALR3 | |
| SCHEMBL5200649 | 0.78 | CYP1A2 (0.43) | LMNASMN1; SMN2MAPTBLMMEN1 | |
| Hydrochloric Acid SCHEMBL717993 | 0.78 | MAPT (0.66) | LMNASMN1; SMN2MAPTBLMGALR3 | |
| Methacrylic Acid SCHEMBL20787977 | 0.77 | TSHR (0.41) | MAPTTSHRMAPK1ALDH1A1THRB | |
| SCHEMBL159608 | 0.77 | TSHR (0.41) | MAPTTSHRMAPK1ALDH1A1THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5132383-A | Salt formation by reacting halohydroxypropyl methacrylate mixtures with trialkylamine; addition polymerization; flocculants | POLYPURE, INC. (US) | 1992-07-21 | — | — | US | claimed |
| EP-0371822-A1 | Copolymers of 3-methacryloyloxy-2-hydroxypropyl trimethylammonium chloride monomer and vinyl monomer | S. N. F. (FR) | 1990-06-06 | — | — | EP | claimed |
| EP-0371822-B1 | Copolymers of 3-methacryloyloxy-2-hydroxypropyl trimethylammonium chloride monomer and vinyl monomer | S N F (FR) | 1996-08-14 | — | — | EP | disclosed |
| EP-0371821-B1 | A process for the production of substituted acryloyloxyhydroxypropyltrialkylammonium chloride | RHONE POULENC SPEC CHIM (US) | 1994-05-25 | — | — | EP | disclosed |
| US-5132383-A | Salt formation by reacting halohydroxypropyl methacrylate mixtures with trialkylamine; addition polymerization; flocculants | POLYPURE, INC. (US) | 1992-07-21 | — | — | US | disclosed |
| US-5132383-A | Salt formation by reacting halohydroxypropyl methacrylate mixtures with trialkylamine; addition polymerization; flocculants | POLYPURE, INC. (US) | 1992-07-21 | — | — | US | disclosed |
| US-5008444-A | Reacting halohydroxypropyl (meth)acrylate with trialkylamine in nonsolvent for quaternary salt | POLYPURE, INC. (US) | 1991-04-16 | — | — | US | disclosed |
| EP-0371822-A1 | Copolymers of 3-methacryloyloxy-2-hydroxypropyl trimethylammonium chloride monomer and vinyl monomer | S. N. F. (FR) | 1990-06-06 | — | — | EP | disclosed |
| EP-0371821-A1 | A process for the production of substituted acryloyloxyhydroxypropyltrialkylammonium chloride | RHONE-POULENC SPECIALTY CHEMICALS CO. (US) | 1990-06-06 | — | — | EP | disclosed |
| EP-0371822-A1 | Copolymers of 3-methacryloyloxy-2-hydroxypropyl trimethylammonium chloride monomer and vinyl monomer | S. N. F. (FR) | 1990-06-06 | — | — | EP | disclosed |