Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | F2RL1 | P55085 | 2/20 | 0.44 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.35 |
| ▸ | CDK2 | P24941 | 2/20 | 0.35 |
| ▸ | PPARA | Q07869 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | GRM5 | P41594 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.33 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8993437 | 0.85 | F2RL1 (0.40) | F2RL1PDE10APTGS2GRM2KDR | |
| SCHEMBL8993654 | 0.81 | F2RL1 (0.36) | ALDH1A1L3MBTL1F2RL1GRM2KDR | |
| SCHEMBL25343836 | 0.76 | F2RL1 (0.43) | F2RL1PDE10APTGS2GRM2KDR | |
| SCHEMBL8993495 | 0.75 | PIM1 (0.37) | ALDH1A1L3MBTL1F2RL1GRM2PPARA | |
| SCHEMBL14152872 | 0.74 | KDM4E (0.46) | ALDH1A1L3MBTL1F2RL1PDE10APTGS2 | |
| SCHEMBL31590118 | 0.73 | L3MBTL1 (0.48) | ALDH1A1L3MBTL1F2RL1PDE10APTGS2 | |
| Hydrochloric Acid SCHEMBL29185155 | 0.72 | ALDH1A1 (0.68) | ALDH1A1L3MBTL1CYP2C19HIF1ACDK5 | |
| SCHEMBL28758944 | 0.71 | PTGS2 (0.51) | F2RL1PDE10APTGS2GRM2KDR | |
| SCHEMBL15465608 | 0.71 | PSMB5 (0.47) | F2RL1PDE10APTGS2KDRCCNE1 | |
| SCHEMBL15465246 | 0.71 | MAP4K4 (0.41) | F2RL1PDE10APTGS2KDRCCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0724566-A1 | 1,2-DIARYLCYCLOPENTENYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-08-07 | — | — | EP | disclosed |
| WO-1995011883-A1 | 1,2-DIARYLCYCLOPENTENYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1995-05-04 | — | — | WO | disclosed |