Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 3/20 | 0.50 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.46 |
| ▸ | KLK1 | P06870 | 1/20 | 0.41 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.37 |
| ▸ | THRA | P10827 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | LSS | P48449 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8994945 | 0.88 | LTB4R (0.55) | LTB4RLTB4R2SRD5A2HTTGAA | |
| SCHEMBL8994929 | 0.83 | LTB4R (0.62) | LTB4RLTB4R2KLK1HTTLMNA | |
| SCHEMBL8994977 | 0.82 | LTB4R (0.48) | LTB4RLTB4R2SRD5A2HTTGAA | |
| SCHEMBL8994878 | 0.82 | LTB4R (0.50) | LTB4RLTB4R2SRD5A2HTTGAA | |
| SCHEMBL8994943 | 0.82 | LTB4R (0.50) | LTB4RLTB4R2SRD5A2HTTGAA | |
| SCHEMBL8995036 | 0.82 | LTB4R (0.48) | LTB4RLTB4R2SRD5A2HTTGAA | |
| SCHEMBL8994887 | 0.81 | LTB4R (0.76) | LTB4RLTB4R2TSHRPLA2G4BTHRA | |
| SCHEMBL8995079 | 0.80 | LTB4R (0.48) | LTB4RLTB4R2TP53THRATHRB | |
| SCHEMBL8995071 | 0.79 | LTB4R (0.56) | LTB4RLTB4R2HTTPLA2G4BTHRA | |
| Hydrochloric Acid SCHEMBL8994980 | 0.78 | LTB4R (0.56) | LTB4RLTB4R2PLA2G4BTHRATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5488160-A | LEUKOTRIENE B4 RECEPTOR ANTAGONIST AS ANTIINFLAMMATORY AGENTS | CIBA-GEIGY CORPORATION (US) | 1996-01-30 | — | — | US | disclosed |
| US-5451700-A | Leukotriene inhibitors | CIBA-GEIGY CORPORATION (US) | 1995-09-19 | — | — | US | disclosed |
| EP-0518819-B1 | Amidino compounds, their manufacture and use as medicament | CIBA GEIGY AG (CH) | 1995-08-02 | — | — | EP | disclosed |