Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 2/20 | 0.55 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.43 |
| ▸ | PRMT1 | Q99873 | 3/20 | 0.42 |
| ▸ | F2 | P00734 | 2/20 | 0.42 |
| ▸ | ST14 | Q9Y5Y6 | 2/20 | 0.42 |
| ▸ | PLAU | P00749 | 1/20 | 0.42 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.42 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.42 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.42 |
| ▸ | TMPRSS2 | O15393 | 1/20 | 0.42 |
| ▸ | PTP4A3 | O75365 | 1/20 | 0.42 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8994878 | 0.89 | LTB4R (0.50) | LTB4RLTB4R2GAAHTTTP53 | |
| SCHEMBL8994943 | 0.89 | LTB4R (0.50) | LTB4RLTB4R2GAAHTTTP53 | |
| SCHEMBL8994920 | 0.88 | LTB4R (0.50) | LTB4RLTB4R2GAAHTTTP53 | |
| SCHEMBL8994887 | 0.87 | LTB4R (0.76) | LTB4RLTB4R2TSHRPLA2G4B | |
| SCHEMBL8994977 | 0.87 | LTB4R (0.48) | LTB4RLTB4R2GAAHTTTP53 | |
| SCHEMBL8995079 | 0.87 | LTB4R (0.48) | LTB4RLTB4R2TP53F2PLAU | |
| SCHEMBL8995036 | 0.86 | LTB4R (0.48) | LTB4RLTB4R2GAAHTTTP53 | |
| SCHEMBL8995071 | 0.85 | LTB4R (0.56) | LTB4RLTB4R2HTTPLA2G4B | |
| SCHEMBL8994948 | 0.85 | LTB4R (0.59) | LTB4RLTB4R2HTTPLA2G4B | |
| SCHEMBL8995027 | 0.85 | NPC1 (0.54) | GAAHTTTP53TSHRPLA2G4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5488160-A | LEUKOTRIENE B4 RECEPTOR ANTAGONIST AS ANTIINFLAMMATORY AGENTS | CIBA-GEIGY CORPORATION (US) | 1996-01-30 | — | — | US | disclosed |
| US-5451700-A | Leukotriene inhibitors | CIBA-GEIGY CORPORATION (US) | 1995-09-19 | — | — | US | disclosed |
| EP-0518819-B1 | Amidino compounds, their manufacture and use as medicament | CIBA GEIGY AG (CH) | 1995-08-02 | — | — | EP | disclosed |