Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 2/20 | 0.50 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.46 |
| ▸ | THRA | P10827 | 2/20 | 0.41 |
| ▸ | THRB | P10828 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.39 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | RARB | P10826 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8994977 | 0.89 | LTB4R (0.48) | LTB4RLTB4R2THRATHRBMEN1 | |
| SCHEMBL8994878 | 0.89 | LTB4R (0.50) | LTB4RLTB4R2THRATHRBMEN1 | |
| SCHEMBL8994945 | 0.89 | LTB4R (0.55) | LTB4RLTB4R2MEN1KMT2AHTT | |
| Hydrochloric Acid SCHEMBL8995006 | 0.86 | LTB4R (0.64) | LTB4RLTB4R2PKMHTTALDH1A1 | |
| SCHEMBL8995079 | 0.83 | LTB4R (0.48) | LTB4RLTB4R2THRATHRBHPGD | |
| SCHEMBL8994920 | 0.82 | LTB4R (0.50) | LTB4RLTB4R2THRATHRBHTT | |
| SCHEMBL8995036 | 0.82 | LTB4R (0.48) | LTB4RLTB4R2THRATHRBMEN1 | |
| SCHEMBL8994887 | 0.81 | LTB4R (0.76) | LTB4RLTB4R2THRATHRBTSHR | |
| SCHEMBL8995071 | 0.81 | LTB4R (0.56) | LTB4RLTB4R2THRATHRBHTT | |
| Hydrochloric Acid SCHEMBL8994980 | 0.81 | LTB4R (0.56) | LTB4RLTB4R2THRATHRBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5488160-A | LEUKOTRIENE B4 RECEPTOR ANTAGONIST AS ANTIINFLAMMATORY AGENTS | CIBA-GEIGY CORPORATION (US) | 1996-01-30 | — | — | US | disclosed |
| US-5451700-A | Leukotriene inhibitors | CIBA-GEIGY CORPORATION (US) | 1995-09-19 | — | — | US | disclosed |
| EP-0518819-B1 | Amidino compounds, their manufacture and use as medicament | CIBA GEIGY AG (CH) | 1995-08-02 | — | — | EP | disclosed |