Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 3/20 | 0.62 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.57 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.46 |
| ▸ | THRA | P10827 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 2/20 | 0.39 |
| ▸ | DRD3 | P35462 | 2/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8994894 | 0.89 | LTB4R (0.67) | LTB4RLTB4R2PLA2G4BTHRATHRB | |
| SCHEMBL8995034 | 0.87 | LTB4R (0.64) | LTB4RLTB4R2PLA2G4BTHRATHRB | |
| SCHEMBL8994854 | 0.86 | LTB4R (0.62) | LTB4RLTB4R2PLA2G4BMAPT | |
| SCHEMBL8995062 | 0.85 | LTB4R (0.61) | LTB4RLTB4R2PLA2G4BTHRATHRB | |
| SCHEMBL8994902 | 0.80 | LTB4R (0.72) | LTB4RLTB4R2PLA2G4BTHRATHRB | |
| SCHEMBL8994895 | 0.80 | LTB4R (0.72) | LTB4RLTB4R2PLA2G4BTHRATHRB | |
| SCHEMBL8994928 | 0.79 | LTB4R (0.84) | LTB4RLTB4R2PLA2G4BTHRATHRB | |
| SCHEMBL9120860 | 0.79 | LTB4R (0.70) | LTB4RLTB4R2PLA2G4BTHRATHRB | |
| SCHEMBL6138115 | 0.78 | LTB4R (0.74) | LTB4RLTB4R2PLA2G4BMAPTHTR1A | |
| SCHEMBL9120857 | 0.78 | LTB4R (0.61) | LTB4RLTB4R2PLA2G4BTHRATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5488160-A | LEUKOTRIENE B4 RECEPTOR ANTAGONIST AS ANTIINFLAMMATORY AGENTS | CIBA-GEIGY CORPORATION (US) | 1996-01-30 | — | — | US | disclosed |
| US-5451700-A | Leukotriene inhibitors | CIBA-GEIGY CORPORATION (US) | 1995-09-19 | — | — | US | disclosed |