Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 3/20 | 0.67 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 2/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | THRA | P10827 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | PPARD | Q03181 | 1/20 | 0.39 |
| ▸ | PPARA | Q07869 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8995034 | 0.90 | LTB4R (0.64) | LTB4RLTB4R2MAPTPLA2G4BMAOB | |
| SCHEMBL8994991 | 0.89 | LTB4R (0.62) | LTB4RLTB4R2MAPTPLA2G4BDRD2 | |
| SCHEMBL8994854 | 0.89 | LTB4R (0.62) | LTB4RLTB4R2MAPTPLA2G4BPPARG | |
| SCHEMBL8995062 | 0.88 | LTB4R (0.61) | LTB4RLTB4R2MAPTPLA2G4BMAOB | |
| SCHEMBL8995047 | 0.88 | LTB4R (0.47) | LTB4RLTB4R2PLA2G4BHRH3 | |
| SCHEMBL8994891 | 0.83 | LTB4R (0.75) | LTB4RLTB4R2MAPTPLA2G4BMAOB | |
| SCHEMBL8994928 | 0.82 | LTB4R (0.84) | LTB4RLTB4R2MAPTPLA2G4BMAOB | |
| SCHEMBL6138115 | 0.81 | LTB4R (0.74) | LTB4RLTB4R2MAPTPLA2G4BPPARG | |
| SCHEMBL8748241 | 0.81 | LTB4R (0.78) | LTB4RLTB4R2MAPTPLA2G4BMAOB | |
| SCHEMBL8747956 | 0.81 | LTB4R (0.78) | LTB4RLTB4R2MAPTPLA2G4BMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5488160-A | LEUKOTRIENE B4 RECEPTOR ANTAGONIST AS ANTIINFLAMMATORY AGENTS | CIBA-GEIGY CORPORATION (US) | 1996-01-30 | — | — | US | disclosed |
| US-5451700-A | Leukotriene inhibitors | CIBA-GEIGY CORPORATION (US) | 1995-09-19 | — | — | US | disclosed |