SCHEMBL8995713

SCHEMBL8995713

CCCOC(OCCC)[SiH2]c1cccc(N)c1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.41
CYP3A4 P08684 3/20 0.39
TP53 P04637 2/20 0.39
ALDH1A1 P00352 4/20 0.36
KDM4E B2RXH2 3/20 0.36
CASP1 P29466 2/20 0.36
MEN1 O00255 1/20 0.36
USP2 O75604 1/20 0.36
POLB P06746 1/20 0.36
GAA P10253 1/20 0.36
MAPT P10636 1/20 0.36
HTT P42858 1/20 0.36
CASP7 P55210 1/20 0.36
KMT2A Q03164 1/20 0.36
ATM Q13315 1/20 0.36
RECQL P46063 1/20 0.34
LMNA P02545 1/20 0.31
ENPP2 Q13822 1/20 0.31
ELANE P08246 1/20 0.30
MAOB P27338 2/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9804112 0.80 MAPT (0.36) TSHRCYP3A4TP53ALDH1A1KDM4E
SCHEMBL31094240 0.79 LMNA (0.36) TSHRALDH1A1KDM4EMEN1HTT
SCHEMBL9804229 0.78 ALDH1A1 (0.44) TSHRCYP3A4TP53ALDH1A1KDM4E
SCHEMBL30038673 0.78 ALDH1A1 (0.44) TSHRCYP3A4TP53ALDH1A1KDM4E
SCHEMBL23493417 0.77 TP53 (0.39) TP53MEN1KMT2A
SCHEMBL29434616 0.77 TP53 (0.39) TP53MEN1KMT2A
SCHEMBL705704 0.77 LPL (0.30)
SCHEMBL29434654 0.76 HPGD (0.33) KMT2ALMNA
SCHEMBL23493484 0.76 HPGD (0.33) KMT2ALMNA
SCHEMBL27659960 0.69 CYP3A4 (0.55) TSHRCYP3A4TP53ALDH1A1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0330456-B1 Preparation of silicon-containing polyimide precursor and cured polyimides obtained therefrom CHISSO CORP (JP) 1994-09-07 EP claimed
EP-0216007-B1 PROCESS FOR PRODUCING ORGANIC SILICON-TERMINATED POLYIMIDE PRECURSOR AND POLYIMIDE HITACHI, LTD. (JP) 1991-03-13 EP claimed
US-4748228-A Process for producing organic silicon-terminated polyimide precursor and polyimide HITACHI. LTD. (JP) 1988-05-31 US claimed
EP-0216007-A2 Process for producing organic silicon-terminated polyimide precursor and polyimide HITACHI, LTD. (JP) 1987-04-01 EP claimed
EP-0381506-B1 Silicon polyimide precursor composition CHISSO CORP (JP) 1996-12-18 EP disclosed
EP-0456469-B1 Photosensitive heat-resistant polymer having hydroxyphenyl group CHISSO CORP (JP) 1996-08-21 EP disclosed
US-5342739-A Coating a substrate with a polyamic acid modified by an amino- or hydroxy-substituted phenol; shelf life CHISSO CORPORATION (JP) 1994-08-30 US disclosed
US-5320935-A Method of forming a pattern from a photosensitive heat-resistant poly(amide)imide having hydroxyphenyl groups CHISSO CORPORATION (JP) 1994-06-14 US disclosed
US-5298359-A Combined with initiator,, an azide, an unsaturated compound CHISSO CORPORATION (JP) 1994-03-29 US disclosed
EP-0337698-B1 Photosensitive Polymer CHISSO CORP (JP) 1993-11-10 EP disclosed
EP-0526650-A1 PHOTOSENSITIVE POLYMER COMPOSITION AND PATTERN FORMATION CHISSO CORPORATION (JP) 1993-02-10 EP disclosed
US-5071908-A Crosslinking a polyamic acid modified by an amine-containing silane by a silicon compound; hard, tough films; heat resistance; adhesion CHISSO CORPORATION (JP) 1991-12-10 US disclosed
EP-0456469-A2 Photosensitive heat-resistant polymer having hydroxyphenyl group Chisso Corporation (JP) 1991-11-13 EP disclosed
EP-0216007-B1 PROCESS FOR PRODUCING ORGANIC SILICON-TERMINATED POLYIMIDE PRECURSOR AND POLYIMIDE HITACHI, LTD. (JP) 1991-03-13 EP disclosed
EP-0381506-A2 Silicon polyimide precursor composition Chisso Corporation (JP) 1990-08-08 EP disclosed
EP-0216007-A2 Process for producing organic silicon-terminated polyimide precursor and polyimide HITACHI, LTD. (JP) 1987-04-01 EP disclosed