Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 3/20 | 0.64 |
| ▸ | HTR1D | P28221 | 1/20 | 0.64 |
| ▸ | HTR2B | P41595 | 1/20 | 0.64 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | HRH1 | P35367 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | HTR7 | P34969 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8995895 | 0.88 | HTR1A (0.73) | HTR1AHTR1DHTR2BALDH1A1LMNA | |
| SCHEMBL8995910 | 0.85 | HTR1A (0.64) | HTR1AHTR1DHTR2BDRD2CYP1A2 | |
| SCHEMBL8995900 | 0.82 | HTR1A (0.68) | HTR1AHTR1DHTR2BDRD2ALDH1A1 | |
| SCHEMBL8065712 | 0.78 | HTR1A (1.00) | HTR1AHTR1DHTR2BDRD2HTR2A | |
| SCHEMBL6546383 | 0.78 | HTR1A (1.00) | HTR1AHTR1DHTR2BDRD2HTR2A | |
| SCHEMBL8995907 | 0.75 | HPGD (0.56) | KDM4EMAPTALDH1A1LMNATP53 | |
| SCHEMBL8653021 | 0.73 | HTR1A (0.66) | HTR1AHTR1DHTR2BDRD2HTR2A | |
| SCHEMBL8652998 | 0.72 | HTR1A (0.62) | HTR1AHTR1DHTR2BDRD2HTR2A | |
| SCHEMBL8653834 | 0.71 | HTR1A (0.63) | HTR1AHTR1DHTR2BDRD2HTR2A | |
| SCHEMBL8653841 | 0.71 | HTR1A (0.63) | HTR1AHTR1DHTR2BDRD2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5541179-A | Tropon-2-one piperazine carboxamides as serotonergic agents | AMERICAN HOME PRODUCTS CORPORATION (US) | 1996-07-30 | — | — | US | disclosed |