Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | PDE4A | P27815 | 1/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | RAD52 | P43351 | 1/20 | 0.44 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5685094 | 0.99 | NPC1 (0.50) | TP53NPC1KMT2AMEN1SMN1; SMN2 | |
| Iodide SCHEMBL8995956 | 0.86 | HTT (0.49) | TP53NPC1KMT2AMEN1HTT | |
| SCHEMBL8995970 | 0.84 | HTT (0.50) | TP53NPC1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL8996014 | 0.80 | CTSD (0.49) | TP53NPC1KMT2ASMN1; SMN2HTT | |
| SCHEMBL27822041 | 0.79 | NPC1 (0.60) | TP53NPC1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL9732890 | 0.77 | NPC1 (0.58) | TP53NPC1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL27912491 | 0.76 | NPC1 (0.57) | TP53NPC1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL28110058 | 0.76 | NPC1 (0.57) | TP53NPC1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL11122619 | 0.76 | ALDH1A1 (0.49) | KMT2AMEN1SMN1; SMN2HTTLMNA | |
| SCHEMBL27914482 | 0.76 | NPC1 (0.57) | TP53NPC1KMT2AMEN1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0572986-B1 | Assay for serum cholinesterase | JOHNSON & JOHNSON CLIN DIAG (US) | 1996-08-28 | — | — | EP | claimed |
| EP-0572986-A1 | Assay for serum cholinesterase | Johnson & Johnson Clinical Diagnostics, Inc. (US) | 1993-12-08 | — | — | EP | claimed |