Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.41 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 4/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8995970 | 0.99 | HTT (0.50) | HTTCHRM2CHRM1CHRM3NPC1 | |
| Iodide SCHEMBL8995953 | 0.86 | TP53 (0.49) | HTTNPC1RAB9AMEN1KMT2A | |
| SCHEMBL5685094 | 0.84 | NPC1 (0.50) | HTTNPC1RAB9AMEN1KMT2A | |
| Iodide SCHEMBL8995949 | 0.82 | HSD11B1 (0.41) | HTTNPC1RAB9AMEN1KMT2A | |
| SCHEMBL8995979 | 0.81 | HSD11B1 (0.42) | HTTNPC1RAB9AMEN1KMT2A | |
| SCHEMBL11122619 | 0.79 | ALDH1A1 (0.49) | HTTMEN1KMT2AALDH1A1CYP1A2 | |
| SCHEMBL757099 | 0.76 | HTT (0.55) | HTTCHRM1NPC1RAB9AMEN1 | |
| SCHEMBL4624134 | 0.74 | SLC6A2 (0.42) | HTTNPC1RAB9AMEN1KMT2A | |
| SCHEMBL1922571 | 0.73 | HTT (0.53) | HTTCHRM1NPC1RAB9AMEN1 | |
| SCHEMBL27508922 | 0.73 | HTT (0.56) | HTTNPC1RAB9AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0572986-B1 | Assay for serum cholinesterase | JOHNSON & JOHNSON CLIN DIAG (US) | 1996-08-28 | — | — | EP | claimed |
| EP-0572986-A1 | Assay for serum cholinesterase | Johnson & Johnson Clinical Diagnostics, Inc. (US) | 1993-12-08 | — | — | EP | claimed |
| JP-6166662-A | — | — | None | — | — | JP | disclosed |
| EP-0572986-B1 | Assay for serum cholinesterase | JOHNSON & JOHNSON CLIN DIAG (US) | 1996-08-28 | — | — | EP | disclosed |
| JP-H06166662-A | COMPOUND FOR ASSAY FOR SERUM CHOLINESTERASE, COMPOSITION, COMPONENT AND METHOD THEREFOR | EASTMAN KODAK CO | 1994-06-14 | — | — | JP | disclosed |
| EP-0572986-A1 | Assay for serum cholinesterase | Johnson & Johnson Clinical Diagnostics, Inc. (US) | 1993-12-08 | — | — | EP | disclosed |