Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 17/20 | 0.68 |
| ▸ | AR | P10275 | 1/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.51 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11698867 | 0.84 | EPHX2 (0.68) | EPHX2MEN1KMT2ARAB9A | |
| SCHEMBL6724207 | 0.84 | EPHX2 (0.67) | EPHX2 | |
| SCHEMBL6158255 | 0.76 | SIGMAR1 (0.53) | EPHX2SIGMAR1RAB9A | |
| Hydrochloric Acid SCHEMBL8874234 | 0.75 | SIGMAR1 (0.54) | EPHX2SIGMAR1RAB9A | |
| SCHEMBL3079393 | 0.73 | EPHX2 (0.58) | EPHX2SIGMAR1 | |
| SCHEMBL678775 | 0.72 | CXCR3 (0.51) | EPHX2ARKCNH2SIGMAR1 | |
| Hydrochloric Acid SCHEMBL6158167 | 0.71 | EPHX2 (0.56) | EPHX2SIGMAR1 | |
| SCHEMBL6719601 | 0.70 | ALDH1A1 (0.51) | EPHX2MEN1KMT2ARAB9A | |
| SCHEMBL26690409 | 0.70 | EPHX2 (0.41) | EPHX2ARKCNH2SIGMAR1 | |
| SCHEMBL6155754 | 0.70 | SIGMAR1 (0.55) | EPHX2SIGMAR1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5574070-A | Substituted guanidines having high binding to the sigma receptor and the use thereof | STATE OF OREGON, ACTING BY AND THROUGH THE OREGON STATE BOARD OF HIGHER EDUCATION, ACTING FOR AND ON BEHALF OF THE OREGON HEALTH SCIENCES UNIVERSITY (US) | 1996-11-12 | — | — | US | claimed |
| EP-0532642-A4 | — | — | 1994-04-27 | — | — | EP | claimed |
| EP-0532642-A1 | SUBSTITUTED GUANIDINES HAVING HIGH BINDING TO THE SIGMA RECEPTOR AND THE USE THEREOF | STATE OF OREGON, acting through OREGON STATE BOARD OF HIGHER EDUCATION, acting for OREGON HEALTH SC. UNIV. AND UNIV. OF OREGON (US) | 1993-03-24 | — | — | EP | claimed |
| WO-1991018868-A1 | SUBSTITUTED GUANIDINES HAVING HIGH BINDING TO THE SIGMA RECEPTOR AND THE USE THEREOF | STATE OF OREGON, acting by and through the OREGON STATE BOARD OF HIGHER EDUCATION, acting for and onbehalf of the OREGON HEALTH SCIENCES UNIVERSITY (US) | 1991-12-12 | — | — | WO | claimed |