Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | HTR7 | P34969 | 1/20 | 0.36 |
| ▸ | ICMT | O60725 | 1/20 | 0.35 |
| ▸ | MGLL | Q99685 | 1/20 | 0.35 |
| ▸ | AR | P10275 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | DRD4 | P21917 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8996705 | 0.89 | ALOX5 (0.45) | ALOX5HTR7MGLLMAPTCYP1A2 | |
| SCHEMBL6160288 | 0.70 | SIGMAR1 (0.52) | ALOX5MGLLSMN1; SMN2ALDH1A1NISCH | |
| SCHEMBL21257474 | 0.68 | MAPT (0.50) | ICMTMAPTCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL10990076 | 0.68 | RAPGEF4 (0.50) | ICMTMAPTCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL6160283 | 0.68 | ALOX5 (0.40) | ALOX5HTR7MGLLMAPTCYP1A2 | |
| SCHEMBL24709283 | 0.66 | SIGMAR1 (0.54) | ALOX5HTR7MAPTCYP2D6MEN1 | |
| SCHEMBL10684601 | 0.65 | RAPGEF4 (0.47) | ICMTMAPTCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL9316519 | 0.65 | SYK (0.50) | ICMTMAPTCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL18461175 | 0.65 | RAPGEF4 (0.47) | ICMTMAPTCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL28044646 | 0.65 | RAPGEF4 (0.47) | ICMTMAPTCYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5574070-A | Substituted guanidines having high binding to the sigma receptor and the use thereof | STATE OF OREGON, ACTING BY AND THROUGH THE OREGON STATE BOARD OF HIGHER EDUCATION, ACTING FOR AND ON BEHALF OF THE OREGON HEALTH SCIENCES UNIVERSITY (US) | 1996-11-12 | — | — | US | disclosed |