SCHEMBL8997215

SCHEMBL8997215

Cn1ncc(C#N)c1NC(=O)CCl

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTGS1 P23219 4/20 0.55
PTGS2 P35354 4/20 0.55
ALDH1A1 P00352 8/20 0.50
SMN1; SMN2 Q16637 6/20 0.50
TP53 P04637 1/20 0.50
HPGD P15428 2/20 0.48
CYP1A2 P05177 1/20 0.47
CYP3A4 P08684 1/20 0.47
CYP2D6 P10635 1/20 0.47
CYP2C9 P11712 1/20 0.47
CYP2C19 P33261 1/20 0.47
HTT P42858 7/20 0.47
L3MBTL1 Q9Y468 1/20 0.47
LMNA P02545 5/20 0.43
TSHR P16473 1/20 0.43
MITF O75030 3/20 0.42
NPC1 O15118 2/20 0.42
MAPT P10636 3/20 0.41
RAB9A P51151 2/20 0.41
GFER P55789 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20540355 0.81 SMN1; SMN2 (0.54) PTGS1PTGS2ALDH1A1SMN1; SMN2TP53
SCHEMBL29174925 0.81 CYP1A2 (0.46) PTGS1PTGS2ALDH1A1SMN1; SMN2TP53
SCHEMBL10937844 0.78 ALDH1A1 (0.51) ALDH1A1SMN1; SMN2TP53HTTL3MBTL1
SCHEMBL8997249 0.75 CYP1A2 (0.56) PTGS1PTGS2ALDH1A1SMN1; SMN2TP53
SCHEMBL8997219 0.74 PTGS1 (0.58) PTGS1PTGS2ALDH1A1SMN1; SMN2TP53
SCHEMBL8997267 0.70 CYP3A4 (0.51) ALDH1A1SMN1; SMN2TP53HPGDCYP1A2
SCHEMBL25702930 0.69 POLB (0.39) ALDH1A1SMN1; SMN2TP53HPGDCYP1A2
SCHEMBL8997373 0.69 POLB (0.39) ALDH1A1SMN1; SMN2TP53HPGDCYP1A2
SCHEMBL8554538 0.68 PTGS1 (0.54) PTGS1PTGS2ALDH1A1SMN1; SMN2TP53
SCHEMBL2420106 0.68 PTGS2 (0.40) PTGS1PTGS2ALDH1A1SMN1; SMN2TP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0561836-A1 SUBSTITUTED 5-AMINOPYRAZOLS BASF Aktiengesellschaft (DE) 1993-09-29 EP claimed
WO-1992010480-A1 SUBSTITUTED 5-AMINOPYRAZOLS BASF AKTIENGESELLSCHAFT (DE) 1992-06-25 WO claimed
US-5486618-A PLANT SAFENING AGENTS BASF AKTIENGESELLSCHAFT (DE) 1996-01-23 US disclosed
US-5486618-A PLANT SAFENING AGENTS BASF AKTIENGESELLSCHAFT (DE) 1996-01-23 US disclosed
EP-0561836-A1 SUBSTITUTED 5-AMINOPYRAZOLS BASF Aktiengesellschaft (DE) 1993-09-29 EP disclosed
EP-0561836-A1 SUBSTITUTED 5-AMINOPYRAZOLS BASF Aktiengesellschaft (DE) 1993-09-29 EP disclosed
WO-1992010480-A1 SUBSTITUTED 5-AMINOPYRAZOLS BASF AKTIENGESELLSCHAFT (DE) 1992-06-25 WO disclosed
WO-1992010480-A1 SUBSTITUTED 5-AMINOPYRAZOLS BASF AKTIENGESELLSCHAFT (DE) 1992-06-25 WO disclosed