SCHEMBL8997320

SCHEMBL8997320

NC(=O)CCCCCS(=O)(=O)c1ccccc1-c1ccccc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC1 Q13547 2/20 0.45
HDAC2 Q92769 2/20 0.45
HDAC3 O15379 1/20 0.44
HDAC4 P56524 1/20 0.44
HDAC7 Q8WUI4 1/20 0.44
HDAC10 Q969S8 1/20 0.44
HDAC11 Q96DB2 1/20 0.44
HDAC8 Q9BY41 1/20 0.44
HDAC6 Q9UBN7 1/20 0.44
HDAC9 Q9UKV0 1/20 0.44
HDAC5 Q9UQL6 1/20 0.44
BCAT2 O15382 1/20 0.40
APEX1 P27695 1/20 0.40
ALOX5AP P20292 1/20 0.39
FEN1 P39748 1/20 0.39
CASP1 P29466 2/20 0.39
SOAT1 P35610 2/20 0.39
LTB4R Q15722 1/20 0.39
MMP2 P08253 2/20 0.37
MMP9 P14780 2/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5592399 0.90 APEX1 (0.47) HDAC1HDAC2HDAC3HDAC4HDAC7
SCHEMBL7208440 0.81 CA2 (0.44) APEX1ALOX5APFEN1CASP1ALDH1A1
SCHEMBL4629650 0.80 ALOX5AP (0.52) ALOX5APFEN1SOAT1MMP9
SCHEMBL7603506 0.78 KDM4E (0.38) HDAC1HDAC2ALOX5APFEN1CASP1
Bromide SCHEMBL7514738 0.78 ALOX5AP (0.41) ALOX5APFEN1CASP1ALDH1A1
SCHEMBL4629540 0.78 ALOX5AP (0.50) ALOX5APFEN1SOAT1
SCHEMBL2807341 0.78 HDAC1 (0.69) HDAC1HDAC2HDAC3HDAC4HDAC7
SCHEMBL11466743 0.78 HDAC1 (0.69) HDAC1HDAC2HDAC3HDAC4HDAC7
SCHEMBL7773680 0.78 HDAC1 (0.69) HDAC1HDAC2HDAC3HDAC4HDAC7
SCHEMBL2703944 0.76 ALOX5AP (0.46) ALOX5APFEN1SOAT1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5512681-A HORMONE INHIBITORS FOR TREATMENT OF HYPERTENSION OR CONGESTIVE HEART FAILURE E. I. DU PONT DE NEMOURS AND COMPANY (US) 1996-04-30 US claimed
US-5512681-A HORMONE INHIBITORS FOR TREATMENT OF HYPERTENSION OR CONGESTIVE HEART FAILURE E. I. DU PONT DE NEMOURS AND COMPANY (US) 1996-04-30 US disclosed