Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.38 |
| ▸ | ALOX5AP | P20292 | 5/20 | 0.41 |
| ▸ | FEN1 | P39748 | 4/20 | 0.41 |
| ▸ | DPP4 | P27487 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | ATR | Q13535 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7208440 | 0.83 | CA2 (0.44) | ALOX5APFEN1KDM4EALDH1A1HPGD | |
| SCHEMBL7212096 | 0.81 | MMP8 (0.47) | ALOX5APFEN1KDM4EALDH1A1HPGD | |
| SCHEMBL2703944 | 0.81 | ALOX5AP (0.46) | ALOX5APFEN1KDM4EALDH1A1HPGD | |
| SCHEMBL7603506 | 0.80 | KDM4E (0.38) | ALOX5APFEN1KDM4EALDH1A1HPGD | |
| SCHEMBL4629540 | 0.80 | ALOX5AP (0.50) | ALOX5APFEN1HPGDTP53 | |
| SCHEMBL4629650 | 0.79 | ALOX5AP (0.52) | ALOX5APFEN1 | |
| SCHEMBL8997320 | 0.78 | HDAC1 (0.45) | ALOX5APFEN1ALDH1A1CASP1 | |
| SCHEMBL29386971 | 0.78 | KDM4E (0.43) | ALOX5APFEN1KDM4EALDH1A1HPGD | |
| SCHEMBL2704545 | 0.77 | ALOX5AP (0.48) | ALOX5APFEN1KDM4EALDH1A1HPGD | |
| SCHEMBL5592399 | 0.76 | APEX1 (0.47) | ALDH1A1CASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0817778-A1 | REVERSIBLE PROTEASE INHIBITORS | ARRIS PHARMACEUTICAL CORPORATION (US) | 1998-01-14 | — | — | EP | disclosed |
| WO-1996030353-A1 | REVERSIBLE PROTEASE INHIBITORS | ARRIS PHARMACEUTICAL CORPORATION (US) | 1996-10-03 | — | — | WO | disclosed |