Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 2/20 | 0.50 |
| ▸ | FEN1 | P39748 | 2/20 | 0.50 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | SOAT1 | P35610 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | EDNRB | P24530 | 1/20 | 0.40 |
| ▸ | EDNRA | P25101 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4629650 | 0.98 | ALOX5AP (0.52) | ALOX5APFEN1PTPN1EPHX2SOAT1 | |
| SCHEMBL2703944 | 0.95 | ALOX5AP (0.46) | ALOX5APFEN1PTPN1SOAT1TP53 | |
| SCHEMBL2704545 | 0.88 | ALOX5AP (0.48) | ALOX5APFEN1HPGDEDNRBEDNRA | |
| SCHEMBL7603506 | 0.83 | KDM4E (0.38) | ALOX5APFEN1HPGDEDNRBEDNRA | |
| SCHEMBL7208440 | 0.83 | CA2 (0.44) | ALOX5APFEN1HPGD | |
| SCHEMBL2445897 | 0.83 | ALOX5AP (0.47) | ALOX5APFEN1 | |
| SCHEMBL2704655 | 0.82 | PSIP1 (0.50) | ALOX5APFEN1SMN1; SMN2HPGDEDNRB | |
| SCHEMBL29700187 | 0.81 | PGAM1 (0.42) | ALOX5APFEN1EPHX2SOAT1TP53 | |
| SCHEMBL7212096 | 0.81 | MMP8 (0.47) | ALOX5APFEN1HPGDEDNRBEDNRA | |
| SCHEMBL29386971 | 0.81 | KDM4E (0.43) | ALOX5APFEN1SMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1919907-A2 | HETEROCYCLIC COMPOUND | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2008-05-14 | — | — | EP | disclosed |
| WO-2007026959-A2 | DERIVATIVES OF 4-PIPERAZIN-1-YL-4-BENZ0 [B] THIOPHENE SUITABLE FOR THE TREATMENT OF CNS DISORDERS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2007-03-08 | — | — | WO | disclosed |