Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 5/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | CASP1 | P29466 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.43 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.43 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | PTPRC | P08575 | 1/20 | 0.40 |
| ▸ | PTPRG | P23470 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.39 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11801596 | 0.84 | ALDH1A1 (0.48) | TSHRALDH1A1TP53CASP1SMN1; SMN2 | |
| SCHEMBL29041506 | 0.83 | TSHR (0.52) | TSHRALDH1A1TP53CASP1SMN1; SMN2 | |
| SCHEMBL3940987 | 0.81 | TSHR (0.47) | TSHRALDH1A1TP53CASP1SMN1; SMN2 | |
| SCHEMBL8751491 | 0.81 | KMT2A (0.50) | TSHRALDH1A1CASP1CSNK2A1KDM4E | |
| SCHEMBL750562 | 0.81 | ALDH1A1 (0.38) | TSHRALDH1A1TP53CASP1SMN1; SMN2 | |
| SCHEMBL432644 | 0.79 | TSHR (0.64) | TSHRALDH1A1TP53CASP1SMN1; SMN2 | |
| SCHEMBL29886586 | 0.79 | TSHR (0.64) | TSHRALDH1A1TP53CASP1SMN1; SMN2 | |
| SCHEMBL23582080 | 0.79 | CLCN2 (0.45) | TSHRALDH1A1TP53CASP1SMN1; SMN2 | |
| SCHEMBL7555550 | 0.79 | TSHR (0.44) | TSHRALDH1A1TP53CASP1SMN1; SMN2 | |
| SCHEMBL478797 | 0.79 | TSHR (0.44) | TSHRALDH1A1TP53CASP1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11077090-B2 | Compounds and compositions and uses thereof | SUNOVION PHARMACEUTICALS INC. (MA) | 2021-08-03 | — | — | US | disclosed |
| CN-109983001-A | 2, 5-disubstituted 3-methylpyrazine and 2,5, 6-trisubstituted 3-methylpyrazine as allosteric SHP2 inhibitors | 锐新医药公司 | 2019-07-05 | — | — | CN | disclosed |
| EP-3490607-A1 | COMPOUNDS AND COMPOSITIONS AND USES THEREOF | Sunovion Pharmaceuticals Inc. (US) | 2019-06-05 | — | — | EP | disclosed |
| WO-2018023070-A1 | COMPOUNDS AND COMPOSITIONS AND USES THEREOF | SUNOVION PHARMACEUTICALS, INC. (US) | 2018-02-01 | — | — | WO | disclosed |
| WO-2018023070-A1 | COMPOUNDS AND COMPOSITIONS AND USES THEREOF | SUNOVION PHARMACEUTICALS, INC. (US) | 2018-02-01 | — | — | WO | disclosed |
| US-20180028492-A1 | COMPOUNDS AND COMPOSITIONS AND USES THEREOF | PGI DRUG DISCOVERY LLC | 2018-02-01 | — | — | US | disclosed |
| US-5514719-A | Fungicidal phenylbenzamides | RHONE-POULENC AGROCHIMIE (FR) | 1996-05-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11077090-B2 | Compounds and compositions and uses thereof | ACHE, CHAT, MAOB | TSHR 4126/4885ALDH1A1 173/4885TP53 4493/4885 |
| US-20180028492-A1 | COMPOUNDS AND COMPOSITIONS AND USES THEREOF | ACHE, CHAT, MAOB | TSHR 4126/4885ALDH1A1 173/4885TP53 4493/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.