Sugi Predict

Sugi Predict / Compounds / SCHEMBL478797

SCHEMBL478797

SCHEMBL478797

O=C(O)c1ccc(Cl)c(F)c1Br

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TSHR P16473 3/20 0.44
▸ ALDH1A1 P00352 2/20 0.44
▸ TP53 P04637 1/20 0.44
▸ CASP1 P29466 1/20 0.44
▸ SMN1; SMN2 Q16637 1/20 0.44
▸ USP2 O75604 1/20 0.42
▸ HPGD P15428 1/20 0.42
▸ NOTUM Q6P988 1/20 0.40
▸ CYP1A2 P05177 1/20 0.39
▸ CLCN2 P51788 2/20 0.39
▸ ADRA2A P08913 1/20 0.39
▸ TDP1 Q9NUW8 2/20 0.39
▸ MYC P01106 1/20 0.39
▸ NR4A1 P22736 1/20 0.39
▸ CTSB P07858 1/20 0.39
▸ SORT1 Q99523 2/20 0.38
▸ KDM4E B2RXH2 1/20 0.38
▸ NPC1 O15118 1/20 0.38
▸ POLB P06746 1/20 0.38
▸ MAPT P10636 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27972922 0.84 TSHR (0.44) TSHRALDH1A1TP53CASP1SMN1; SMN2
SCHEMBL14861075 0.82 KMT2A (0.47) ALDH1A1CASP1USP2HPGDSORT1
SCHEMBL478785 0.82 HPGD (0.41) ALDH1A1SMN1; SMN2USP2HPGDNOTUM
SCHEMBL30343106 0.82 HPGD (0.41) ALDH1A1SMN1; SMN2USP2HPGDNOTUM
SCHEMBL14118416 0.82 HPGD (0.38) TSHRALDH1A1TP53CASP1SMN1; SMN2
SCHEMBL11801596 0.81 ALDH1A1 (0.48) TSHRALDH1A1TP53CASP1SMN1; SMN2
SCHEMBL20721983 0.81 HPGD (0.55) TSHRALDH1A1TP53CASP1SMN1; SMN2
SCHEMBL107955 0.79 TSHR (0.52) TSHRALDH1A1TP53CASP1SMN1; SMN2
SCHEMBL7558115 0.79 CES2 (0.50) TSHRALDH1A1CASP1SMN1; SMN2CYP1A2
SCHEMBL8997789 0.79 TSHR (0.52) TSHRALDH1A1TP53CASP1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 114 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12404274-B2 Macrocycles as factor xia inhibitors BRISTOL-MYERS SQUIBB COMPANY (US) 2025-09-02 — — US disclosed
US-12398120-B2 Substituted hydantoinamides as ADAMTS7 antagonists BAYER AKTIENGESELLSCHAFT (DE) 2025-08-26 — — US disclosed
CN-118184669-A Macrocyclic compounds as multi-target kinase inhibitors 北京伯汇生物技术有限公司 2024-06-14 — — CN disclosed
EP-4058448-B1 HYDANTOIN DERIVATIVES AS ADAMTS7 ANTAGONISTS FOR THE TREATMENT OF CARDIOVASCULAR DISEASES BAYER AG (DE) 2024-05-29 — — EP disclosed
US-11976083-B2 Inhibitors of peptidylarginine deiminases GILEAD SCIENCES, INC. (US) 2024-05-07 — — US disclosed
CN-115551862-B Macrocyclic inhibitors of peptidyl arginine deiminase 吉利德科学公司 2024-04-12 — — CN disclosed
US-11897880-B2 7,8-dihydrobenzo[e]pyrido[3,4-c]azocine-2,5(3H,6H)-dione derivatives useful as a factor XIa inhibitors JANSSEN PHARMACEUTICA NV (BE) 2024-02-13 — — US disclosed
EP-3793994-B1 INHIBITING AGENTS FOR BRUTON'S TYROSINE KINASE BIOGEN MA INC (US) 2023-08-23 — — EP disclosed
EP-3793994-B1 INHIBITING AGENTS FOR BRUTON'S TYROSINE KINASE BIOGEN MA INC (US) 2023-08-23 — — EP disclosed
EP-3500556-B1 PYRIDINE-1-OXIDE DERIVATIVES AND THEIR USE AS FACTOR XIA INHIBITORS MERCK SHARP & DOHME LLC (US) 2023-08-02 — — EP disclosed
US-20110021492-A1 PYRIDAZINE DERIVATIVES AS FACTOR XIA INHIBITORS BRISTOL-MYERS SQUIBB COMPANY 2011-01-27 — — US disclosed
EP-2265601-A1 PYRIDAZINE DERIVATIVES AS FACTOR XIA INHIBITORS Bristol-Myers Squibb Company (US) 2010-12-29 — — EP disclosed
WO-2009114677-A1 PYRIDAZINE DERIVATIVES AS FACTOR XIA INHIBITORS BRISTOL-MYERS SQUIBB COMPANY (US) 2009-09-17 — — WO disclosed
EP-0734380-B1 4-BENZOYLISOXAZOLES AND THEIR USE AS HERBICIDES AVENTIS AGRICULTURE LTD (GB) 2002-07-10 — — EP disclosed
US-6114538-A 2-POSITION OF BENZOY RING OF 4-BENZOYLISOXAZOLE DERIVATIVE IS SUBSTITUTED AND PARTICULARLY USED AGAINST MONOCOTYLEDONOUS WEEDS BY POST-EMEREGENECE APPLICATION RHONE POULENC AGRICULTURE LIMITED (GB) 2000-09-05 — — US disclosed
US-5998653-A CHEMICAL INTERMEDIATE FOR HERBICIDES RHONE POULENC AGRICULTURE LIMITED (GB) 1999-12-07 — — US disclosed
US-5658858-A POSTEMERGENCE HERBICIDES RHONE-POULENC ARGRICULTURE LIMITED (GB) 1997-08-19 — — US disclosed
CN-1137271-A 4-benzoylisoxazoles and their use as herbicides RHONE POULENC AGRICULTURE (GB) 1996-12-04 — — CN disclosed
EP-0734380-A1 4-BENZOYLISOXAZOLES AND THEIR USE AS HERBICIDES RHONE-POULENC AGRICULTURE LTD. (GB) 1996-10-02 — — EP disclosed
WO-1995016678-A1 4-BENZOYLISOXAZOLES AND THEIR USE AS HERBICIDES RHONE POULENC AGRICULTURE LIMITED (GB) 1995-06-22 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11897880-B2 7,8-dihydrobenzo[e]pyrido[3,4-c]azocine-2,5(3H,6H)-dione derivatives useful as a factor XIa inhibitors F2, F13B, SERPINE1 TSHR 3776/4885ALDH1A1 2124/4885TP53 4685/4885
US-12404274-B2 Macrocycles as factor xia inhibitors TFPI, TFPI2, F11 TSHR 2404/4885ALDH1A1 4598/4885TP53 4774/4885
US-20110021492-A1 PYRIDAZINE DERIVATIVES AS FACTOR XIA INHIBITORS F11, F12, TFPI2 TSHR 1896/4885ALDH1A1 2830/4885TP53 4346/4885
US-11976083-B2 Inhibitors of peptidylarginine deiminases PADI4, PADI2, PADI1 TSHR 1815/4885ALDH1A1 2537/4885TP53 506/4885
US-12398120-B2 Substituted hydantoinamides as ADAMTS7 antagonists ADAMTS7, MMP7, ADAM17 TSHR 1345/4885ALDH1A1 3828/4885TP53 4448/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.