Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | MET | P08581 | 1/20 | 0.47 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.47 |
| ▸ | TRIM24 | O15164 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | ACVRL1 | P37023 | 4/20 | 0.44 |
| ▸ | ACVR1 | Q04771 | 4/20 | 0.44 |
| ▸ | BMPR1B | O00238 | 3/20 | 0.44 |
| ▸ | AADAT | Q8N5Z0 | 1/20 | 0.44 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.44 |
| ▸ | BMPR1A | P36894 | 3/20 | 0.44 |
| ▸ | PKM | P14618 | 2/20 | 0.43 |
| ▸ | TDP2 | O95551 | 1/20 | 0.43 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.43 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.43 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12245376 | 0.85 | TRIM24 (0.47) | LMNAPOLBTRIM24ALDH1A1GAA | |
| SCHEMBL1899211 | 0.84 | LMNA (0.55) | LMNAPOLBMETTRIM24ACVRL1 | |
| SCHEMBL8998849 | 0.80 | NOTUM (0.43) | LMNAPOLBNOTUMALDH1A1AADAT | |
| SCHEMBL9582543 | 0.80 | FFAR1 (0.47) | LMNAPOLBALDH1A1GAAPKM | |
| SCHEMBL248856 | 0.78 | NOTUM (0.56) | LMNAPOLBNOTUMALDH1A1GAA | |
| SCHEMBL769477 | 0.78 | ACVRL1 (0.63) | ACVRL1ACVR1BMPR1BBMPR1A | |
| SCHEMBL12160587 | 0.78 | TDP2 (0.48) | LMNAPOLBMETNOTUMSRD5A1 | |
| SCHEMBL8999096 | 0.77 | TRIM24 (0.49) | LMNAPOLBNOTUMTRIM24ALDH1A1 | |
| SCHEMBL11807706 | 0.77 | MEN1 (0.47) | LMNAPOLBTDP2MEN1KMT2A | |
| SCHEMBL434054 | 0.75 | TRIM24 (0.54) | LMNAPOLBTRIM24ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5556874-A | ENZYME INHIBITORS AS ANTICARCINOGENIC AGENTS | WARNER LAMBERT COMPANY (US) | 1996-09-17 | — | — | US | disclosed |
| US-5464861-A | Anticarcinogenic agents | WARNER-LAMBERT (US) | 1995-11-07 | — | — | US | disclosed |
| EP-0654024-A1 | 2-THIOINDOLES (SELENOINDOLES) AND RELATED DISULFIDES (SELENIDES) WHICH INHIBIT PROTEIN TYROSINE KINASES AND WHICH HAVE ANTITUMOR PROPERTIES | WARNER-LAMBERT COMPANY (US) | 1995-05-24 | — | — | EP | disclosed |
| WO-1994003427-A1 | 2-THIOINDOLES (SELENOINDOLES) AND RELATED DISULFIDES (SELENIDES) WHICH INHIBIT PROTEIN TYROSINE KINASES AND WHICH HAVE ANTITUMOR PROPERTIES | WARNER-LAMBERT COMPANY (US) | 1994-02-17 | — | — | WO | disclosed |
| US-4160032-A | Oxindoles as sleep-inducers | SANDOZ, INC. (US) | 1979-07-03 | — | — | US | disclosed |