Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.54 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.53 |
| ▸ | NCOR2 | Q9Y618 | 5/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.53 |
| ▸ | KCNT1 | Q5JUK3 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | TACR1 | P25103 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | CTSL | P07711 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8999337 | 0.94 | GPR84 (0.54) | GPR84HDAC3HDAC1HDAC2NCOR2 | |
| SCHEMBL8998979 | 0.88 | KCNT1 (0.55) | HDAC3HDAC1HDAC2NCOR2HDAC6 | |
| SCHEMBL1388421 | 0.87 | KCNT1 (0.60) | KCNT1KMT2AMAPTGAAHTT | |
| SCHEMBL8999157 | 0.86 | KMT2A (0.51) | GPR84KCNT1KMT2AMAPTGAA | |
| SCHEMBL8998802 | 0.80 | KMT2A (0.51) | GPR84KCNT1KMT2AMAPTGAA | |
| SCHEMBL8998993 | 0.80 | KCNT1 (0.60) | KCNT1KMT2AMAPTGAAHTT | |
| SCHEMBL8999124 | 0.80 | KMT2A (0.53) | KMT2AMAPTGAAPOLBLMNA | |
| SCHEMBL27839975 | 0.80 | CTSL (0.69) | HDAC3HDAC1HDAC2NCOR2HDAC6 | |
| SCHEMBL8999294 | 0.78 | KCNT1 (0.52) | KCNT1KMT2AMAPTGAAHTT | |
| SCHEMBL8998901 | 0.78 | MAPT (0.64) | GPR84KMT2AMAPTGAAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5556874-A | ENZYME INHIBITORS AS ANTICARCINOGENIC AGENTS | WARNER LAMBERT COMPANY (US) | 1996-09-17 | — | — | US | disclosed |
| US-5464861-A | Anticarcinogenic agents | WARNER-LAMBERT (US) | 1995-11-07 | — | — | US | disclosed |
| EP-0654024-A1 | 2-THIOINDOLES (SELENOINDOLES) AND RELATED DISULFIDES (SELENIDES) WHICH INHIBIT PROTEIN TYROSINE KINASES AND WHICH HAVE ANTITUMOR PROPERTIES | WARNER-LAMBERT COMPANY (US) | 1995-05-24 | — | — | EP | disclosed |
| WO-1994003427-A1 | 2-THIOINDOLES (SELENOINDOLES) AND RELATED DISULFIDES (SELENIDES) WHICH INHIBIT PROTEIN TYROSINE KINASES AND WHICH HAVE ANTITUMOR PROPERTIES | WARNER-LAMBERT COMPANY (US) | 1994-02-17 | — | — | WO | disclosed |