SCHEMBL8999364

SCHEMBL8999364

CO[Si](C)(OC)c1ccccc1Oc1ccccc1

nearest known ligand 0.45

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.45
MAPK1 P28482 1/20 0.45
HTT P42858 1/20 0.45
L3MBTL1 Q9Y468 1/20 0.45
LTA4H P09960 2/20 0.42
TSHR P16473 2/20 0.41
RIPK1 Q13546 1/20 0.41
SLC6A2 P23975 1/20 0.41
SLC6A4 P31645 1/20 0.41
LMNA P02545 1/20 0.40
GAA P10253 1/20 0.40
KMT2A Q03164 1/20 0.40
CA4 P22748 1/20 0.38
HRH1 P35367 1/20 0.38
CTNNB1 P35222 1/20 0.38
TSPO P30536 1/20 0.38
FAAH O00519 1/20 0.38
HPGD P15428 1/20 0.37
TTR P02766 3/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16487320 0.85 ALDH1A1 (0.45) ALDH1A1MAPK1HTTL3MBTL1LTA4H
SCHEMBL18096790 0.82 ALDH1A1 (0.47) ALDH1A1MAPK1HTTL3MBTL1LTA4H
SCHEMBL3091248 0.82 HTT (0.47) ALDH1A1MAPK1HTTL3MBTL1LTA4H
SCHEMBL24631916 0.82 LTA4H (0.46) ALDH1A1MAPK1HTTL3MBTL1LTA4H
SCHEMBL27707263 0.79 CA1 (0.52) ALDH1A1MAPK1HTTL3MBTL1TSHR
SCHEMBL18096787 0.79 HTT (0.48) ALDH1A1MAPK1HTTL3MBTL1LTA4H
SCHEMBL18096728 0.79 LTA4H (0.50) ALDH1A1MAPK1HTTL3MBTL1LTA4H
SCHEMBL1930744 0.78 ALDH1A1 (0.42) ALDH1A1MAPK1HTTL3MBTL1LTA4H
SCHEMBL1929591 0.78 ALDH1A1 (0.42) ALDH1A1MAPK1HTTL3MBTL1LTA4H
SCHEMBL30473475 0.76 CA4 (0.36) ALDH1A1MAPK1TSHRCA4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0492966-B1 A stereospecific catalyst system intended for the polymerization of olefins BOREALIS AS (DK) 1996-08-21 EP claimed
US-5227355-A STEREOSPECIFIC CATALYST SYSTEM INTENDED FOR THE POLYMERIZATION OF OLEFINS Seppala, Jukka (FI) 1993-07-13 US claimed
EP-0492966-A2 A stereospecific catalyst system intended for the polymerization of olefins BOREALIS A/S (DK) 1992-07-01 EP claimed
US-9884927-B2 Heterogeneous ziegler-natta catalyst system and a process for olefin polymerization using the same RELIANCE INDUSTRIES LIMITED (IN) 2018-02-06 US disclosed
US-20150344593-A1 Heterogeneous Ziegler-Natta Catalyst System And A Process For Olefin Polymerization Using The Same RELIANCE INDUSTRIES LIMITED (IN) 2015-12-03 US disclosed
EP-0492966-B1 A stereospecific catalyst system intended for the polymerization of olefins BOREALIS AS (DK) 1996-08-21 EP disclosed
EP-0492966-A2 A stereospecific catalyst system intended for the polymerization of olefins BOREALIS A/S (DK) 1992-07-01 EP disclosed