SCHEMBL1929591

SCHEMBL1929591

CO[Si](OC)(c1ccccc1)c1ccccc1Oc1ccccc1

nearest known ligand 0.42

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.42
MAPK1 P28482 1/20 0.42
HTT P42858 1/20 0.42
L3MBTL1 Q9Y468 1/20 0.42
LTA4H P09960 2/20 0.39
TSHR P16473 2/20 0.39
RIPK1 Q13546 1/20 0.39
SLC6A2 P23975 1/20 0.39
SLC6A4 P31645 1/20 0.39
LMNA P02545 1/20 0.38
GAA P10253 1/20 0.38
KMT2A Q03164 1/20 0.38
HRH1 P35367 1/20 0.36
CTNNB1 P35222 1/20 0.36
TSPO P30536 1/20 0.36
CA4 P22748 1/20 0.35
HPGD P15428 1/20 0.35
TTR P02766 3/20 0.35
RAB9A P51151 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18096790 0.91 ALDH1A1 (0.47) ALDH1A1MAPK1HTTL3MBTL1LTA4H
SCHEMBL1930744 0.82 ALDH1A1 (0.42) ALDH1A1MAPK1HTTL3MBTL1LTA4H
SCHEMBL8642129 0.80 CA4 (0.36) ALDH1A1LTA4HTSHRKMT2ACA4
SCHEMBL3091248 0.79 HTT (0.47) ALDH1A1MAPK1HTTL3MBTL1LTA4H
SCHEMBL8999364 0.78 ALDH1A1 (0.45) ALDH1A1MAPK1HTTL3MBTL1LTA4H
SCHEMBL16487320 0.78 ALDH1A1 (0.45) ALDH1A1MAPK1HTTL3MBTL1LTA4H
SCHEMBL1929693 0.77 LTA4H (0.56) ALDH1A1HTTLTA4HTSHRKMT2A
SCHEMBL3972186 0.77 LTA4H (0.56) ALDH1A1HTTLTA4HTSHRKMT2A
SCHEMBL18096787 0.76 HTT (0.48) ALDH1A1MAPK1HTTL3MBTL1LTA4H
SCHEMBL18096728 0.76 LTA4H (0.50) ALDH1A1MAPK1HTTL3MBTL1LTA4H

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2019106-B1 (Thio)Phenoxy Phenyl Silane Composition And Method For Making Same ROHM & HAAS (US) 2013-11-27 EP disclosed
US-7956125-B2 (Thio)phenoxy phenyl silane compostion and method for making same ROHM AND HAAS COMPANY (US) 2011-06-07 US disclosed
US-20090039313-A1 (Thio)phenoxy phenyl silane compostion and method for making same ROHM AND HAAS COMPANY (US) 2009-02-12 US disclosed
EP-2019106-A1 (Thio)Phenoxy Phenyl Silane Composition And Method For Making Same Rohm and Haas Company (US) 2009-01-28 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090039313-A1 (Thio)phenoxy phenyl silane compostion and method for making same TPMT, TTR, TST ALDH1A1 2237/4885MAPK1 4346/4885HTT 32/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.