Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | F2 | P00734 | 1/20 | 0.39 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.39 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.39 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.39 |
| ▸ | MCOLN3 | Q8TDD5 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.36 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8972696 | 0.80 | MAPT (0.38) | TSHRCA1CA2CA9ALDH1A1 | |
| SCHEMBL1219713 | 0.75 | TSHR (0.46) | TSHRLMNAL3MBTL1AKR1B1SLC6A2 | |
| SCHEMBL8799250 | 0.73 | CA1 (0.45) | TSHRAKR1B1F2PRSS1PRSS2 | |
| SCHEMBL29397944 | 0.72 | LMNA (0.47) | TSHRLMNAL3MBTL1AKR1B1F2 | |
| SCHEMBL144642 | 0.72 | LMNA (0.47) | TSHRLMNAL3MBTL1AKR1B1F2 | |
| SCHEMBL5275182 | 0.68 | TSHR (0.59) | TSHRLMNAL3MBTL1SLC6A2SLC6A4 | |
| SCHEMBL2829814 | 0.68 | TDP1 (0.54) | LMNASLC6A2SLC6A4KMT2AALDH1A1 | |
| SCHEMBL1952494 | 0.66 | LMNA (0.68) | TSHRLMNAL3MBTL1AKR1B1F2 | |
| SCHEMBL3212630 | 0.66 | PKM (0.55) | TSHRLMNAL3MBTL1SLC6A2SLC6A4 | |
| SCHEMBL6169176 | 0.65 | ALDH1A1 (0.40) | KMT2ACA1CA2CA9ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0444546-B1 | Hydantoin derivatives for use as hypoglycemic and/or hypolipidemic agents | MOCHIDA PHARM CO LTD (JP) | 1996-09-11 | — | — | EP | disclosed |