Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MMP13 | P45452 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.36 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | SOAT1 | P35610 | 2/20 | 0.36 |
| ▸ | DHODH | Q02127 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9000729 | 0.95 | EPHX1 (0.41) | EPHX1MAPTSMN1; SMN2LMNAMMP13 | |
| SCHEMBL9000458 | 0.95 | EPHX1 (0.41) | EPHX1MAPTSMN1; SMN2LMNAMMP13 | |
| SCHEMBL9000768 | 0.95 | EPHX1 (0.41) | EPHX1MAPTSMN1; SMN2LMNAMMP13 | |
| SCHEMBL9000878 | 0.95 | EPHX1 (0.41) | EPHX1MAPTSMN1; SMN2LMNAMMP13 | |
| SCHEMBL9000398 | 0.95 | EPHX1 (0.47) | EPHX1MAPTSMN1; SMN2LMNAL3MBTL1 | |
| SCHEMBL9000898 | 0.94 | EPHX1 (0.46) | EPHX1MAPTL3MBTL1ALDH1A1CYP3A4 | |
| SCHEMBL9000708 | 0.92 | EPHX1 (0.38) | EPHX1MAPTSMN1; SMN2LMNAMMP13 | |
| SCHEMBL9000745 | 0.88 | EPHX1 (0.41) | EPHX1MAPTSMN1; SMN2LMNASOAT1 | |
| SCHEMBL9000777 | 0.88 | KMT2A (0.37) | LMNACYP3A4SOAT1DHODHMEN1 | |
| SCHEMBL9000588 | 0.88 | EPHX1 (0.38) | EPHX1LMNAL3MBTL1ALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5583147-A | INHIBITORS OF ACYL-COENZYME A: CHOLESTEROL O-TRANSFERASE; ANTIHYPERCHOLESTEROLEMIC AND/OR ANTIATHEROSCLEROTIC AGENTS | THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) | 1996-12-10 | — | — | US | disclosed |