Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 2/20 | 0.38 |
| ▸ | SOAT1 | P35610 | 5/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | ACACB | O00763 | 1/20 | 0.34 |
| ▸ | ACACA | Q13085 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9000608 | 0.94 | FNTA (0.37) | EPHX1SOAT1L3MBTL1GRM5LMNA | |
| SCHEMBL9000673 | 0.93 | SOAT1 (0.37) | EPHX1SOAT1GRM5 | |
| SCHEMBL9000398 | 0.93 | EPHX1 (0.47) | EPHX1SOAT1L3MBTL1LMNA | |
| SCHEMBL9000651 | 0.92 | SOAT1 (0.41) | EPHX1SOAT1ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL9000460 | 0.90 | EPHX1 (0.37) | EPHX1SOAT1GRM5ALDH1A1 | |
| SCHEMBL9000575 | 0.90 | SOAT1 (0.39) | SOAT1ALDH1A1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL9000506 | 0.90 | SOAT1 (0.39) | SOAT1L3MBTL1ALDH1A1LMNA | |
| SCHEMBL9000714 | 0.90 | GPR88 (0.39) | EPHX1SOAT1L3MBTL1ALDH1A1CYP2C19 | |
| SCHEMBL9000445 | 0.89 | POLB (0.43) | EPHX1SOAT1ALDH1A1LMNA | |
| SCHEMBL9000753 | 0.89 | SOAT1 (0.39) | EPHX1SOAT1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5583147-A | INHIBITORS OF ACYL-COENZYME A: CHOLESTEROL O-TRANSFERASE; ANTIHYPERCHOLESTEROLEMIC AND/OR ANTIATHEROSCLEROTIC AGENTS | THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) | 1996-12-10 | — | — | US | disclosed |