Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | SRC | P12931 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MMP13 | P45452 | 1/20 | 0.36 |
| ▸ | KLK7 | P49862 | 4/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | FPR2 | P25090 | 1/20 | 0.35 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.35 |
| ▸ | FNTA | P49354 | 1/20 | 0.35 |
| ▸ | FNTB | P49356 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9000729 | 1.00 | EPHX1 (0.41) | EPHX1CNR2ABL1SRCMAPT | |
| SCHEMBL9000423 | 0.95 | EPHX1 (0.44) | EPHX1MAPTSMN1; SMN2LMNAMMP13 | |
| SCHEMBL9000777 | 0.94 | KMT2A (0.37) | CNR2LMNACYP1A2CYP3A4 | |
| SCHEMBL9000708 | 0.91 | EPHX1 (0.38) | EPHX1MAPTSMN1; SMN2LMNAMMP13 | |
| SCHEMBL9000878 | 0.91 | EPHX1 (0.41) | EPHX1ABL1SRCMAPTSMN1; SMN2 | |
| SCHEMBL9000458 | 0.91 | EPHX1 (0.41) | EPHX1ABL1SRCMAPTSMN1; SMN2 | |
| SCHEMBL9000398 | 0.91 | EPHX1 (0.47) | EPHX1CNR2MAPTSMN1; SMN2LMNA | |
| SCHEMBL9000831 | 0.91 | TOP2A (0.37) | MAPTSMN1; SMN2LMNA | |
| SCHEMBL9000898 | 0.90 | EPHX1 (0.46) | EPHX1MAPTL3MBTL1CYP3A4ALDH1A1 | |
| SCHEMBL9000497 | 0.89 | EPHX1 (0.38) | EPHX1ABL1SRCMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5583147-A | INHIBITORS OF ACYL-COENZYME A: CHOLESTEROL O-TRANSFERASE; ANTIHYPERCHOLESTEROLEMIC AND/OR ANTIATHEROSCLEROTIC AGENTS | THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) | 1996-12-10 | — | — | US | disclosed |