Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 1/20 | 0.37 |
| ▸ | SOAT1 | P35610 | 6/20 | 0.35 |
| ▸ | ANXA2 | P07355 | 1/20 | 0.35 |
| ▸ | S100A10 | P60903 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | MET | P08581 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | BCHE | P06276 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9000777 | 0.97 | KMT2A (0.37) | SOAT1KMT2AMEN1POLBEGFR | |
| SCHEMBL9000753 | 0.93 | SOAT1 (0.39) | SOAT1KMT2AMEN1POLBSMN1; SMN2 | |
| SCHEMBL9000506 | 0.91 | SOAT1 (0.39) | SOAT1POLBSMN1; SMN2RAB9ALMNA | |
| SCHEMBL9000768 | 0.91 | EPHX1 (0.41) | SMN1; SMN2LMNAMAPT | |
| SCHEMBL9000701 | 0.91 | EPHX1 (0.41) | SOAT1KMT2AMEN1POLBEGFR | |
| SCHEMBL9000610 | 0.90 | CTRC (0.39) | SOAT1KMT2AMEN1POLBRAB9A | |
| SCHEMBL9000608 | 0.89 | FNTA (0.37) | SOAT1KMT2ALMNANPSR1 | |
| SCHEMBL9000745 | 0.87 | EPHX1 (0.41) | SOAT1KMT2AMEN1POLBEGFR | |
| SCHEMBL9000722 | 0.87 | SMN1; SMN2 (0.36) | SMN1; SMN2RAB9ALMNAMAPT | |
| SCHEMBL9000511 | 0.86 | ALDH1A1 (0.40) | KMT2AMEN1SMN1; SMN2RAB9ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5583147-A | INHIBITORS OF ACYL-COENZYME A: CHOLESTEROL O-TRANSFERASE; ANTIHYPERCHOLESTEROLEMIC AND/OR ANTIATHEROSCLEROTIC AGENTS | THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) | 1996-12-10 | — | — | US | disclosed |