Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 5/20 | 0.37 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9000787 | 0.91 | LMNA (0.46) | KMT2ALMNAMAPTEPHX1SMN1; SMN2 | |
| SCHEMBL9000745 | 0.90 | EPHX1 (0.41) | KMT2ALMNAMAPTEPHX1SMN1; SMN2 | |
| SCHEMBL9000458 | 0.90 | EPHX1 (0.41) | KMT2ALMNAMAPTEPHX1SMN1; SMN2 | |
| SCHEMBL9000878 | 0.90 | EPHX1 (0.41) | KMT2ALMNAMAPTEPHX1SMN1; SMN2 | |
| SCHEMBL9000671 | 0.86 | EPHX1 (0.34) | KMT2ALMNAMAPTEPHX1POLB | |
| SCHEMBL9000497 | 0.86 | EPHX1 (0.38) | KMT2ALMNAMAPTEPHX1TP53 | |
| SCHEMBL9000445 | 0.86 | POLB (0.43) | KMT2ALMNAMAPTEPHX1POLB | |
| SCHEMBL9000423 | 0.85 | EPHX1 (0.44) | KMT2ALMNAMAPTEPHX1SMN1; SMN2 | |
| SCHEMBL9000733 | 0.84 | PDE2A (0.40) | KMT2ALMNAMAPTEPHX1MEN1 | |
| SCHEMBL9000713 | 0.84 | EPHX1 (0.43) | KMT2ALMNAMAPTEPHX1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5583147-A | INHIBITORS OF ACYL-COENZYME A: CHOLESTEROL O-TRANSFERASE; ANTIHYPERCHOLESTEROLEMIC AND/OR ANTIATHEROSCLEROTIC AGENTS | THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) | 1996-12-10 | — | — | US | disclosed |