Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SOAT1 | P35610 | 5/20 | 0.37 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.37 |
| ▸ | QPCT | Q16769 | 1/20 | 0.37 |
| ▸ | TNF | P01375 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9000786 | 0.91 | KMT2A (0.38) | LMNAMAPTMEN1KMT2AEPHX1 | |
| SCHEMBL9000398 | 0.89 | EPHX1 (0.47) | LMNAMAPTMEN1KMT2ARAB9A | |
| SCHEMBL9000651 | 0.88 | SOAT1 (0.41) | ALDH1A1SOAT1EPHX1SMN1; SMN2 | |
| SCHEMBL9000506 | 0.86 | SOAT1 (0.39) | LMNAALDH1A1RAB9ASOAT1SMN1; SMN2 | |
| SCHEMBL9000575 | 0.86 | SOAT1 (0.39) | MAPTMEN1KMT2AALDH1A1SOAT1 | |
| SCHEMBL9000588 | 0.86 | EPHX1 (0.38) | LMNAALDH1A1SOAT1EPHX1 | |
| SCHEMBL9000839 | 0.86 | SOAT1 (0.38) | LMNAMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL9000798 | 0.86 | QPCT (0.49) | LMNAMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL9000753 | 0.85 | SOAT1 (0.39) | LMNAMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL9000445 | 0.85 | POLB (0.43) | LMNAMAPTMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5583147-A | INHIBITORS OF ACYL-COENZYME A: CHOLESTEROL O-TRANSFERASE; ANTIHYPERCHOLESTEROLEMIC AND/OR ANTIATHEROSCLEROTIC AGENTS | THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) | 1996-12-10 | — | — | US | disclosed |