Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.50 |
| ▸ | LMNA | P02545 | 6/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9000496 | 0.93 | MAPT (0.44) | MAPTLMNATSHRTDP1PKM | |
| SCHEMBL9000950 | 0.93 | MAPT (0.46) | MAPTLMNATSHRTDP1PKM | |
| SCHEMBL9000852 | 0.91 | MAPT (0.52) | MAPTLMNATSHRTDP1PKM | |
| SCHEMBL9000902 | 0.87 | MAPT (0.42) | MAPTLMNATDP1MEN1KMT2A | |
| SCHEMBL9000853 | 0.86 | SOAT1 (0.42) | MAPTLMNAMEN1KMT2ANPSR1 | |
| SCHEMBL9000592 | 0.85 | MAPT (0.44) | MAPTLMNATDP1PKMMEN1 | |
| SCHEMBL9000651 | 0.84 | SOAT1 (0.41) | NPSR1ALDH1A1SMN1; SMN2POLBCYP2C9 | |
| SCHEMBL9000887 | 0.83 | LMNA (0.39) | MAPTLMNAMEN1KMT2ANPSR1 | |
| SCHEMBL9000530 | 0.81 | MAPT (0.41) | MAPTLMNATDP1MEN1KMT2A | |
| SCHEMBL9000642 | 0.81 | MAPT (0.41) | MAPTLMNATDP1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5583147-A | INHIBITORS OF ACYL-COENZYME A: CHOLESTEROL O-TRANSFERASE; ANTIHYPERCHOLESTEROLEMIC AND/OR ANTIATHEROSCLEROTIC AGENTS | THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) | 1996-12-10 | — | — | US | disclosed |